Change of opinion on the use of hydroxychloroquine for COVID-19 treatment and prevention
https://doi.org/10.37489/2588-0519-2020-S4-90-91
Abstract
The use of hydroxychloroquine for COVID-19 treatment and prevention should be restricted in both out- and inpatient settings due to the lack of evidence for effectiveness and unfavorable safety profile.
About the Authors
K. B. Mirzaev
Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia
Russian Federation
Russian Federation
Mirzaev Karin B. – Candidate of Medical Sciences, Associate Professor of the Department of Clinical Pharmacology and Therapy. SPIN code: 8308-7599
Moscow
D. A. Sychev
Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia
Russian Federation
Russian Federation
Sychev Dmitry A. – Doctor of Medical Sciences, Professor, Corresponding Member RAS, Rector, Head. Department of Clinical Pharmacology and Therapy. SPIN code: 4525-7556
Moscow
References
1. Gautret P et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial. Int J Antimicrob Agents. 2020 Jul;56(1):105949. DOI: 10.1016/j.ijantimicag.2020.105949
2. Yao X et al. In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Jul 28;71(15):732-739. DOI: 10.1093/cid/ciaa237
3. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-covid-19-treatments
4. https://www.fda.gov/drugs/drug-safety-and-availability/fda-cautionsagainst-use-hydroxychloroquine-or-chloroquine-covid-19-outside-hospitalsetting-or
5. https://www.tropmedres.ac/covid-19/copcov/copcov-key-messages
6. https://www.recoverytrial.net/news/statement-from-the-chief-investigators-of-the-randomised-evaluation-of-covid-19-therapy-recovery-trial-on-hydroxychloroquine-5-june-2020-no-clinical-benefit-from-use-of-hydroxychloroquine-in-hospitalised-patients-with-covid-19
7. Boulware DR, Pullen MF, Bangdiwala AS, et al. A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19. N Engl J Med. 2020;NEJMoa2016638. DOI: 10.1056/NEJMoa2016638
Review
For citations:
Mirzaev K.B., Sychev D.A. Change of opinion on the use of hydroxychloroquine for COVID-19 treatment and prevention. Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice. 2020;(4S):90-91. (In Russ.) https://doi.org/10.37489/2588-0519-2020-S4-90-91
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