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Possibilities for the use of anakinra in COVID-19

https://doi.org/10.37489/2588-0519-2020-S4-60-63

Abstract

The use of anakinra cannot be currently recommended outside of clinical trials as pathogenetic treatment of “cytokine storm” in severe COVID-19.

About the Authors

V. A. Otdelenov
Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia
Russian Federation

Otdelenov Vitaly A. – Associate Professor of the Department of Clinical Pharmacology and Therapy. SPIN code: 8357-5770

Moscow



A. V. Matveev
Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia
Russian Federation

Matveev Alexander V. – Candidate of Medical Sciences, Associate Professor of the Department of Clinical Pharmacology and Therapy. SPIN code: 8518-1320

Moscow



D. A. Sychev
Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia
Russian Federation

Sychev Dmitry A. – Doctor of Medical Sciences, Professor, Corresponding Member RAS, Rector, Head. Department of Clinical Pharmacology and Therapy. SPIN code: 4525-7556

Moscow



References

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2. Channappanavar R, Perlman S. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Semin Immunopathol. 2017 Jul;39(5):529-539. DOI: 10.1007/s00281-017-0629-x

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9. Brigham and Women’s Hospital COVID-19 Clinical Guidelines Therapeutics — Anti-IL-1 Agents (Anakinra, Canakinumab, Rilonacept) [Internet]. [cited 2020 May 22]; Available from: https://covidprotocols.org/protocols/therapeutics/#anti-il-1-agents-anakinra-canakinumab-rilonacept

10. Filocamo G et al. Use of anakinra in severe COVID-19: a case report. Int J Infect Dis. 2020 Jul;96:607-609. DOI: 10.1016/j.ijid.2020.05.026

11. Franzetti M et al. Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe Coronavirus disease 2019: A case report. Int J Infect Dis. 2020 Aug;97:215-218. DOI: 10.1016/j.ijid.2020.05.050

12. Lopalco G et al. Safety profile of anakinra in the management of rheumatologic, metabolic and autoinflammatory disorders. Clin Exp Rheumatol. Italy, 2016. Vol. 34, No 3. P. 531- 538.

13. Explanations of the Ministry of health of the Russian Federation dated October 30, 2018 About importation to the Russian Federation of the specific party of the unregistered medicines intended for rendering medical care on vital indications of the specific patient. (In Russ). Доступно по: https://www.garant.ru/products/ipo/prime/doc/71995356/ Ссылка активна на 27.05.2020


Review

For citations:


Otdelenov V.A., Matveev A.V., Sychev D.A. Possibilities for the use of anakinra in COVID-19. Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice. 2020;(4S):60-63. (In Russ.) https://doi.org/10.37489/2588-0519-2020-S4-60-63

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ISSN 2588-0519 (Print)
ISSN 2618-8473 (Online)