Analysis of spontaneous reports from a pediatric population: Stevens–Johnson syndrome and toxic epidermal necrolysis induced by antibacterial drugs
https://doi.org/10.37489/2588-0519-2024-3-37-39
EDN: RFDIXW
Abstract
Relevance. Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are cutaneous hypersensitivity reactions that can be induced by drugs and are particularly severe in children.
Objective. To study the structure of antibacterial drugs (ABs) involved in the development of SJS and TEN in pediatric populations.
Methods. Retrospective pharmacoepidemiologic study of spontaneous reports (SRs) entered into the Russian National Pharmacovigilance database during the period 01.04.2019 – 31.12.2023.
Results. The majority of suspected drugs were β-lactams (76.0%), with penicillin accounting for 47.4% and cephalosporins — for 52.6%. Amphenicols (12.0%), macrolides (8.0%), and fluoroquinolones (4.0%) were less frequently reported.
Conclusion. The most common group of ABs that induce SJS and TEN in children is the group of β-lactam antibiotics.
About the Authors
Yu. O. Kustov
Peoples' Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
Yury O. Kustov — Sixth year student of the Faculty of Medicine
Moscow
E. N. Terekhina
Peoples' Friendship University of Russia named after Patrice Lumumba; Information and Methodological Center for Examination, Accounting and Analysis of Circulation of Medical Products of Roszdravnadzor
Russian Federation
Russian Federation
Elizaveta N. Terekhina — 1-year resident of the Department of General and Clinical Pharmacology; Leading Specialist
Moscow
I. L. Asetskaya
Peoples' Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
Irina L. Asetskaya — PhD, Cand. Sci. (Med), Associate Professor of the Department of General and Clinical Pharmacology
Moscow
O. I. Butranova
Peoples' Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
Olga I. Butranova — PhD, Cand. Sci. (Med), Associate Professor of the Department of General and Clinical Pharmacology
Moscow
References
1. Charlton OA, Harris V, Phan K, et al. Toxic Epidermal Necrolysis and Steven-Johnson Syndrome: A Comprehensive Review. Adv Wound Care (New Rochelle). 2020;9(7):426-439. doi: 10.1089/wound.2019.0977.
Review
For citations:
Kustov Yu.O., Terekhina E.N., Asetskaya I.L., Butranova O.I. Analysis of spontaneous reports from a pediatric population: Stevens–Johnson syndrome and toxic epidermal necrolysis induced by antibacterial drugs. Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice. 2024;(3):37-39. (In Russ.) https://doi.org/10.37489/2588-0519-2024-3-37-39. EDN: RFDIXW
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