Anti-infective drugs as etiologic factors for Stevens–Johnson syndrome and toxic epidermal necrolysis according to the Russian database of spontaneous reports
https://doi.org/10.37489/2588-0519-2024-3-34-36
EDN: QIJFMA
Abstract
Relevance. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious adverse drug reactions (ADRs) associated with drug use. Knowledge of drug triggers is important for ADR prevention.
Objective. To study the structure of anti-infective drugs that cause the development of SJS and TEN.
Methods. We studied spontaneous reports (SRs) submitted to the Russian National Pharmacovigilance database from 01.04.2019 to 31.12.2023. SRs about the development of SJS or TEN were included. Suspected drugs in group J according to the ATC classification were analyzed.
Results. Among the 170 included SRs, anti-infectives were noted as suspects in 69, and the total number of drugs was 103. 75 drugs were antibacterial (beta-lactams were leading, n = 46), and 21 were antiviral agents.
Conclusion. In terms of the structure of anti-infective drug triggers, 72.8% were antibacterial drugs and 20.4% were antiviral agents.
About the Authors
E. N. Terekhina
Peoples' Friendship University of Russia named after Patrice Lumumba; Information and Methodological Center for Expert Evaluation, Record and Analysis of Circulation of Medical Products
Russian Federation
Russian Federation
Elizaveta N. Terekhina — 1st year Resident of the Department of General and Clinical Pharmacology; Leading specialist of the Pharmacovigilance
Moscow
I. L. Asetskaya
Peoples' Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
Irina L. Asetskaya — PhD, Cand. Sci. (Med), Associate Professor of the Department of General and Clinical Pharmacology
Moscow
References
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2. Lee EY, Knox C, Phillips EJ. Worldwide Prevalence of Antibiotic-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Meta-analysis. JAMA Dermatol. 2023 Apr 1;159(4):384- 392. doi: 10.1001/jamadermatol.2022.6378.
3. Abulatan IT, Ben-David SG, Morales-Colon LA, et al. A Compilation of Drug Etiologies of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Cureus. 2023 Nov 13;15(11):e48728. doi: 10.7759/cureus.48728.
Review
For citations:
Terekhina E.N., Asetskaya I.L. Anti-infective drugs as etiologic factors for Stevens–Johnson syndrome and toxic epidermal necrolysis according to the Russian database of spontaneous reports. Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice. 2024;(3):34-36. (In Russ.) https://doi.org/10.37489/2588-0519-2024-3-34-36. EDN: QIJFMA
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