The roles of vitamin D in the prevention and the therapy of male infertility
Abstract
The results of fundamental and clinical studies show the importance of providing males with vitamin D in order to (1) assist the formation of the testicles, (2) maintain the steroid-synthesizing and other functions of the testicles, (3) maintain the functioning of the spermatozoa and, in general, maintain the male fertility.
About the Authors
O. A. Gromova
Institute of Modern Information Technologies in Medicine, Federal Research Center «Computer Science and Control», RAS; Federal State Budgetary Educational Institution of Higher Education «Ivanovo State Medical Academy» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
I. Yu. Torshin
Institute of Modern Information Technologies in Medicine, Federal Research Center «Computer Science and Control», RAS; Federal State Budgetary Educational Institution of Higher Education «North State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
T. R. Grishina
FITS of Informatics and Control Sciences (Institute of contemporary information technology in medicine)
Russian Federation
Russian Federation
S. I. Malyavskaya
Federal State Budgetary Educational Institution of Higher Education «North State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
References
1. Громова О.А., Торшин И.Ю. Витамин D - смена парадигмы. М., ГЭОТАР-Медиа, 2017, ISBN: 978-5-9704-4058-2, 568.
2. Anagnostis P., Karras S., Goulis D.G. Vitamin D in human reproduction: a narrative review. Int J Clin Pract. 2013; 67 (3): 225-35 doi.
3. Lerchbaum E., Obermayer-Pietsch B. Vitamin D and fertility: a systematic review. Eur J Endocrinol. 2012; 166 (5): 765-78 doi.
4. Yang B., Sun H., Wan Y., Wang H., Qin W., Yang L., Zhao H., Yuan J., Yao B. Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men. Int J Androl. 2012;35 (6): 783-92 doi.
5. Vanni V.S., Vigano’ P., Somigliana E., Papaleo E., Paffoni A., Pagliardini L., Candiani M. Vitamin D and assisted reproduction technologies: current concepts. Reprod Biol Endocrinol. 2014; 12:47 doi.
6. Lee D.M., Tajar A., Pye S.R., Boonen S., Vanderschueren D., Bouillon R., O’Neill T. W., Bartfai G., Casanueva F.F., Finn J.D., Forti G., Giwercman A., Han T.S., Huhtaniemi I.T., Kula K., Lean M.E., Pendleton N., Punab M., Wu F.C. Association of hypogonadism with vitamin D status: the European Male Ageing Study. Eur J Endocrinol. 2012;166 (1): 77-85 doi.
7. Hammoud A.O., Meikle A.W., Peterson C.M., Stanford J., Gibson M., Carrell D.T. Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl. 2012; 14 (6): 855-9 doi.
8. Zhu C.L., Xu Q.F., Li S.X., Wei Y.C., Zhu G.C., Yang C., Shi Y.C. Investigation of serum vitamin D levels in Chinese infertile men. Andrologia. 2016;Andrologia: 101111/and12570.
9. Громова О.А., Торшин И.Ю., Гилельс А.В., Гришина Т.Р, Томилова И.К. Метаболиты витамина D: роль в диагностике и терапии витамин^-зави-симых патологий, Фармакокинетика и Фармакодинамика, 2016; 4: 9-18.
10. Schleicher G., Privette T.H., Stumpf W.E. Distribution of soltriol [1,25(OH)2-vitamin D3] binding sites in male sex organs of the mouse: an autoradiographic study. J Histochem Cytochem. 1989; 37 (7): 1083-1086.
11. Blomberg Jensen M. Vitamin D metabolism, sex hormones, and male reproductive function. Reproduction. 2012; 144 (2): 135-52 doi.
12. Blomberg Jensen M., Nielsen J.E., Jorgensen A., Rajpert-De Meyts E., Kristensen D.M., Jorgensen N., Skakkebaek N.E., Juul A., Leffers H. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Hum Reprod. 2010; 25 (5): 1303-11 doi.
13. Johnson J.A., Grande J.P, Roche P.C., Kumar R. Immunohistochemical detection and distribution of the 1,25-dihydroxyvitamin D3 receptor in rat reproductive tissues. Histochem Cell Biol. 1996; 105 (1): 7-15.
14. Hofer D., Munzker J., Schwetz V., Ulbing M., Hutz K., Stiegler P., Zigeuner R., Pieber T.R., Muller H., Obermayer-Pietsch B. Testicular synthesis and vitamin D action. J Clin Endocrinol Metab. 2014; 99 (10): 3766-73 doi.
15. Hirai T., Tsujimura A., Ueda T., Fujita K., Matsuoka Y., Takao T., Miyagawa Y., Koike N., Okuyama A. Effect of 1,25-dihydroxyvitamin d on testicular morphology and gene expression in experimental cryptorchid mouse: testis specific cDNA microarray analysis and potential implication in male infertility. J Urol. 2009; 181 (3): 1487-92 doi.
16. Foresta C., Strapazzon G., De Toni L., Perilli L., Di Mambro A., Muciaccia B., Sartori L., Selice R. Bone mineral density and testicular failure: evidence for a role of vitamin D 25-hydroxylase in human testis. J Clin Endocrinol Metab. 2011; 96 (4): E646-52 doi.
17. Vitamin D and male reproduction. Nat Rev Endocrinol. 2014;10 (3): 175-86 doi.
18. Blomberg Jensen M., Jorgensen A., Nielsen J.E., Bjerrum P. J., Skalkam M., Petersen J.H., Egeberg D.L., Bangsboll S., Andersen A.N., Skakkebaek N.E., Juul A., Rajpert-De Meyts E., Dissing S., Leffers H., Jorgensen N. Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality. Int J Androl. 2012; 35 (4): 499-510 doi.
19. Sood S., Marya R.K., Reghunandanan R., Singh G.P., Jaswal T.S., Gopinathan K. Effect of vitamin D deficiency on testicular function in the rat. Ann Nutr Metab. 1992;36 (4): 203-208.
20. Sun W., Chen L., Zhang W., Wang R., Goltzman D., Miao D. Active vitamin D deficiency mediated by extracellular calcium and phosphorus results in male infertility in young mice. Am J Physiol Endocrinol Metab. 2015;308 (1): E51-62 doi.
21. Zanatta L., Bouraima-Lelong H., Delalande C., Silva F.R., Carreau S. Regulation of aromatase expression by 1alpha,25(OH)2 vitamin D3 in rat testicular cells. Reprod Fertil Dev. 2011; 23 (5): 725-35 doi.
22. Sood S., Reghunandanan R., Reghunandanan V., Marya R.K., Singh P.I. Effect of vitamin D repletion on testicular function in vitamin D-deficient rats. Ann Nutr Metab. 1995;39 (2): 95-98.
23. Akerstrom V.L., Walters M.R. Physiological effects of 1,25-dihydroxyvitamin D3 in TM4 Sertoli cell line. Am J Physiol. 1992; 262 (6 Pt 1: E884-E890.
24. Huang Y., Jin H., Chen J., Jiang X., Li P., Ren Y., Liu W., Yao J., Folger J.K., Smith G.W., Lv L. Effect of Vitamin D on basal and Luteinizing Hormone (LH) induced testosterone production and mitochondrial dehydrogenase activity in cultured Leydig cells from immature and mature rams. Anim Reprod Sci. 2015; 158: 109-14 doi.
25. Ding C., Wang Q., Hao Y., Ma X., Wu L., du M., Li W., Wu Y., Guo F., Ma S., Huang F., Qin G. Vitamin D supplement improved testicular function in diabetic rats. Biochem Biophys Res Commun. 2016;473 (1): 161-7 doi.
26. Kumar N., Sood S., Arora B., Singh M., Beena, Roy P.S. To Study the Effect of Vitamin D and E on Sodium-Fluoride-induced Toxicity in Reproductive Functions of Male Rabbits. Toxicol Int. 2012; 19 (2): 182-7 doi.
27. Ребров В.Г., Громова О.А. Витамины, макро- и микроэлементы. М., ГэотарМед, 2008, 968.
28. Eslamian G., Amirjannati N., Rashidkhani B., Sadeghi M.R., Hekmatdoost A. Nutrient patterns and asthenozoospermia: a case-control study. Andrologia. 2016;Andrologia: 101111/and12624.
29. Deng X.L., Li Y.M., Yang X.Y., Huang J.R., Guo S.L., Song L.M. [Efficacy and safety of vitamin D in the treatment of idiopathic oligoasthenozoospermia]. Zhonghua Nan Ke Xue. 2014; 20 (12): 1082-1085.
30. Song Y., Wang L., Pittas A.G. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care. 2013;36 (5): 1422-8 doi.
31. Mitri J. Effects of vitamin D and calcium supplementation on pancreatic beta cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr. 2011; 94 (2): 486-94.
32. Aljabri K.S., Bokhari S.A., Khan M.J. Glycemic changes after vitamin D supplementation in patients with type 1 diabetes mellitus and vitamin D deficiency. Ann Saudi Med. 2010; 30 (6): 454-458.
33. Holick M.F. Evaluation, treatment and Prevention of Vitamin D deficiency: an Endocrine society clinical practice guideline. J Clin Metab. 2011; 9: 1911 - 1930.
Review
For citations:
Gromova O.A., Torshin I.Yu., Grishina T.R., Malyavskaya S.I. The roles of vitamin D in the prevention and the therapy of male infertility. Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice. 2017;(3):61-71. (In Russ.)
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