Main indications for peroral anticoagulants: how to choose an optimal drug
Abstract
Practical approaches to use of oral anticoagulants for prevention and treatment of thrombotic and thromboembolic complications in patients with atrial fibrillation, venous thromboembolism and coronary heart disease are considered. Comparison of main pharmacologic properties of DOACs and warfarin as well as their efficacy and safety in prospective randomized controlled trials are present. Clinical situations with minimal or no evidence for use of DOACs are specified.
About the Author
I. S. Yavelov
FSI “National Medical Research Center for Preventive Medicine”; FGBOU VP RNRMU named after Pirogova N.I
Russian Federation
Russian Federation
References
1. Heidbuchel H., Verhamme P., Alings M., et al. Updated European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist anticoagulants in patients with non-valvular atrial fibrillation. Europace. 2015; 17: 1467-1507.
2. Salmonson T., Dogné J.-M., Janssen H., et al. Non-vitamin-K oral anticoagulants and laboratory testing: now and in the future. Views from a workshop at the European Medicines Agency (EMA). EurHYPERLINK «https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216197/» Heart J Cardiovasc HYPERLINK «https:// www.ncbi.nlm.nih.gov/pmc/articles/PMC5216197/»Pharmacother. 2017; 3: 42-47.
3. Konstantinides S., Torbicki A., Agnelli G., et al. 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism. The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Endorsed by the European Respiratory Society (ERS). Eur Heart J. 2014; 35: 3033-3069.
4. Kearon C., Akl E.A., Ornelas J., et al. Antithrombotic Therapy for VTE Disease. Chest Guideline and Expert Panel Report. Chest. 2016; 149: 315-352.
5. Kirchhof P., Benussi S., Kotecha D., et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC). Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Endorsed by the European Stroke Organisation (ESO). Eur Heart J. 2016; 50: e1-e88.
6. Roffi M., Patrono C., Collet J.P., et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016; 37: 267-315.
7. Schulman S., Kearon C., Kakkar A.K., et al., for the RE-COVER Study Group. Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism. N Engl J Med. 2009; 361: 2342-2352.
8. Schulman S., Kakkar A.K., Goldhaber S.Z., et al., for the RE-COVER II trial investigators. Treatment of Acute Venous Thromboembolism with Dabigatran or Warfarin and Pooled Analysis. Circulation. 2014; 129: 764-772.
9. The EINSTEIN Investigators. Oral Rivaroxaban for Symptomatic Venous Thromboembolism. N Engl J Med. 2010; 363: 2499-2510.
10. The EINSTEIN-PE Investigators. Oral Rivaroxaban for the Treatment of Symptomatic Pulmonary Embolism. N Engl J Med. 2012; 366: 1287-1297.
11. Agnelli G., Buller H.R., Cohen A., et al., for the AMPLIFY Investigators. Oral Apixaban for the Treatment of Acute Venous Thromboembolism. N Engl J Med. 2013; 369: 799-808.
12. Werth S., Bauersachs R., Gerlach H., Rabe E., et al. Superficial vein thrombosis treated for 45 days with rivaroxaban versus fondaparinux: rationale and design of the SURPRISE trial. J Thromb Thrombol. 2016; 42: 197-204.
13. Connolly S.J., Ezekowitz M.D., Yusuf S., et al., the RE-LY Steering Committee and Investigators. Dabigatran versus Warfarin in Patients with Atrial Fibrillation. N Engl J Med. 2009; 361: 1139-1151.
14. Granger C.B., Alexander J.H., McMurray J.J., et al., for the ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011; 365: 981-992.
15. Patel M.R., Mahaffey K.W., Garg J., et al., for the ROCKET-AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011; 365: 883-891.
16. Mega J.L., BraunwaldHYPERLINK «http://www.ncbi.nlm.nih.gov/pubmed/?term=Braunwald%20E%5BAuthor%5D&cauthor=true&cauthor_uid=22077192» E., WiviottHYPERLINK «http://www.ncbi.nlm.nih.gov/pubmed/?term=Wiviott%20SD%5BAuthor%5D&cauthor=true&cauthor_uid=22077192» S.D., et al.; ATLAS ACS 2-TIMI 51 Investigators. Rivaroxaban in patients with a recent acute coronary syndrome. N HYPERLINK «http://www.ncbi.nlm.nih.gov/ pubmed/22077192»EnglHYPERLINK «http://www.ncbi.nlm.nih.gov/pubmed/22077192» J Med. 2012; 366: 9-19.
17. Lip G.Y., Windecker S., Huber K., et al. Management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous coronary or valve interventions: a joint consensus document of the European Society of Cardiology Working Group on Thrombosis, European Heart Rhythm Association (EHRA), European Association of Percutaneous Cardiovascular Interventions (EAPCI) and European Association of Acute Cardiac Care (ACCA) endorsed by the Heart Rhythm Society (HRS) and Asia-Pacific Heart Rhythm Society (APHRS). Eur Heart J. 2014; 35: 3155-3179.
18. Dans A.L., Connolly S.J., Wallentin L., et al. Concomitant Use of Antiplatelet Therapy with Dabigatran or Warfarin in the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) Trial. Circulation. 2013; 127: 634-640.
19. Gibson C.M., Mehran R., Bode C., et al. Prevention of Bleeding in Patients with Atrial Fibrillation Undergoing PCI. N Engl J Med. 2016; 375: 2423-2434.
Review
For citations:
Yavelov I.S. Main indications for peroral anticoagulants: how to choose an optimal drug. Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice. 2017;(3):53-60. (In Russ.)
Views:
48976
Email this article 