Potential use of nanoparticles to improve the effectiveness and safety of pharmacotherapy during pregnancy
https://doi.org/10.37489/2588-0519-2024-4-35-45
EDN: IXHNSD
Abstract
Relevance. Pharmacotherapy during pregnancy is associated with great risks for the fetus in the case of therapy of non-obstetric diseases of the mother, in addition, issues of improving the effectiveness of treatment of placental pathology, thrombophilic conditions, and other pregnancy complications remain a priority. Recently, the possibilities of using nanomaterials in medicine have been actively studied, including for the purpose of modifying the delivery or distribution of medicines.
Objective. The aim was to conduct a structured analysis of the published literature on the use of nanomaterials for therapeutic purposes during pregnancy.
Methods. The analysis of publications in PubMed, Cyberleninka, and eLIBRARY databases on the keywords “Nanoparticles” and “Pregnancy” was carried out, with the exception of mentioning nanoparticles in the context of environmental pollutants, as well as in the context of diagnostic methods.
Results. Information is provided on the nature of nanoparticles that have been developed and studied in the context of the prospect of use during pregnancy. An overview of the areas of clinical application of such materials is provided, as well as the available evidence of their effectiveness and safety.
Conclusion. Therapeutic systems containing drugs and various nanomaterials have a good potential for clinical use in order to ensure targeted drug delivery, modification of their bio-distribution in order to increase clinical efficacy and reduce the toxicity of drugs.
Supporting agencies: The work is done as a part of a project supported by RSF grant project № 23-25-00515.
About the Authors
K. A. Zagorodnikova
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Ksenia A. Zagorodnikova — Cand. Sci (Med.), Associate Professor of the Institute of Medical Education
Saint Petersburg
O. A. Bettikher
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Ofelia A. Bettikher — Cand. Sci (Med), assistant at the Institute of Medical Education
Saint Petersburg
I. Ye. Zazerskaya
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Irina Ye. Zazerskaya — Cand. Sci. (Med), Professor, Head of the Institute of Medical Education
Saint Petersburg
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Zagorodnikova K.A., Bettikher O.A., Zazerskaya I.Ye. Potential use of nanoparticles to improve the effectiveness and safety of pharmacotherapy during pregnancy. Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice. 2024;(4):35-45. (In Russ.) https://doi.org/10.37489/2588-0519-2024-4-35-45. EDN: IXHNSD
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