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Качественная клиническая практика

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Современные аспекты эпидемиологии врождённых аномалий развития: методологические вопросы и трансляция результатов исследований в клиническую практику

https://doi.org/10.24411/2588-0519-2018-10051

Аннотация

Достигнутые успехи в выявлении и характеристике факторов риска возникновения врождённых аномалий происходят в основном благодаря эпидемиологическим исследованиям, давшим многочисленные ассоциации между факторами риска и группами врождённых дефектов. Однако в клинической практике трансляция этих ассоциаций в качестве фактических причин остаётся весьма сложной. Характеристика и эпидемиологический анализ возможных факторов, в частности лекарственных средств, связанных с возникновением врождённых аномалий, имеют решающее значение для разработки профилактических мероприятий, оказывающих воздействие на распространённость дефектов. В дальнейшем уменьшению глобального бремени врождённых дефектов может способствовать интеграция исследований в области эпидемиологии, генетики и эпигенетики через персонализированные и популяционно ориентированные превентивные стратегии.

Об авторах

О. В. Решетько
ФГБОУ ВО Саратовский ГМУ им. В.И. Разумовского Минздрава России
Россия

Решетько Ольга Вилоровна, доктор медицинских наук, профессор, заведующая кафедрой фармакологии

Саратов



К. А. Луцевич
ФГБОУ ВО Саратовский ГМУ им. В.И. Разумовского Минздрава России
Россия

Луцевич Константин Александрович, кандидат медицинских наук, доцент кафедры фармакологии

Саратов



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Рецензия

Для цитирования:


Решетько О.В., Луцевич К.А. Современные аспекты эпидемиологии врождённых аномалий развития: методологические вопросы и трансляция результатов исследований в клиническую практику. Качественная клиническая практика. 2018;(3):56-65. https://doi.org/10.24411/2588-0519-2018-10051

For citation:


Reshetko O.V., Lutsevich K.V. Modern aspects of epidemiology of congenital anomalies of development: methodological issues and the translation of research fndings into clinical practice. Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice. 2018;(3):56-65. (In Russ.) https://doi.org/10.24411/2588-0519-2018-10051

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