Нефротоксичность антибиотиков у новорожденных
Аннотация
Применение антибактериальных препаратов является основной причиной возникновения заболеваний для всех возрастных групп. Повреждение почек происходит посредством двух основных механизмов, в частности напрямую и при помощи иммунологических медиаторов. Для некоторых антибиотиков (аминогликозиды и ванкомицин) нефротоксичностъ, обратимая после отмены препарата, является очень частым побочным эффектом, вплоть до возникновения острой почечной недостаточности, частота возникновения которой в настоящее время возрастает. Антибактериальные препараты очень часто используются в неонаталъном периоде, особенно у новорожденных с очень низкой массой тела при рождении.
Ключевые слова
безопасность лекарств,
нефротоксичность,
антибиотики,
новорожденные,
аминогликозиды,
фторхинолоны,
гликопептиды,
пенициллины,
карбапенемы,
монобактамы
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Рецензия
Для цитирования:
Лукьянова Е.М. Нефротоксичность антибиотиков у новорожденных. Качественная Клиническая Практика. 2002;(2):53-62.
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