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Комбинированные конечные точки в клинических исследованиях: обзор публикаций

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Аннотация

Современная медицина, основанная на доказанном, использует, прежде всего, факты, полученные в специально спланированных клинических испы­таниях. Количество исследований, изучающих раз­личные практически важные проблемы современной клинической медицины, огромно. Новые сведения, способные изменить сложившиеся представления об оптимальных подходах к лечению больных, появляются постоянно, в то время как клинические рекомендации, призванные обобщить и проанализировать современное состояние проблемы и дать практикующему врачу простые инструкции, обнов­ляются достаточно редко. Кроме того, во многих слу­чаях накопленные факты противоречивы и мнения различных групп экспертов не совпадают. Наконец, в случаях, когда нет свидетельств о преимуществе того или иного подхода к лечению, врачам предлага­ется обсудить с больным имеющуюся доказательную базу и активно привлекать его к принятию решения. Всё это побуждает клинициста к самостоятельному анализу накопленных данных, который невозможен без знания принципов, позволяющих оценить значимость результата, полученного в том или ином клиническом испытании. Особую трудность представляет извлечение практического смысла из ре­зультатов исследований, предназначенных для оценки не одного клинически важного события, а совокуп­ности нескольких таких событий. Представленная ниже статья Питера Клейста 'Комбинированные конечные точки в клинических исследованиях. Совре­менные перспективы' (IntJPharm 2007; 21 (3); 187-198) может оказать существенную помощь в понимании результатов подобных исследований и в силу особой актуальности поднятых в ней проблем приводится без сокращений.

Об авторе

И. С. Явелов
ФГБУ «НМИЦ профилактической медицины» МЗ РФ; ФГБОУ ВО «РНИМУ им. Н.И. Пирогова» МЗ РФ
Россия


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Для цитирования:


Явелов И.С. Комбинированные конечные точки в клинических исследованиях: обзор публикаций. Качественная клиническая практика. 2010;(1):39-53.

For citation:


. . Kachestvennaya klinicheskaya praktika. 2010;(1):39-53. (In Russ.)

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