Resolution of the Expert Council on the use of pazufloxacin

Abstract

   The resolution of the Expert Council is devoted to the use of fluoroquinolones, in particular pazufloxacin, in the context of increasing antibiotic resistance. It is noted that fluoroquinolones, especially parenteral forms, remain an important tool for treating infections caused by resistant bacterial strains, such as ESBL-producing E. coli and K. pneumoniae. However, the growth of resistance to traditional fluoroquinolones (for example, ciprofloxacin and levofloxacin) requires a search for new solutions. Pazufloxacin, as a new representative of fluoroquinolones, has low cross-resistance, a broad spectrum of action, and high efficacy at low doses. The drug demonstrates minimal toxicity, including a low risk of neuro-, cardio- and phototoxicity, as well as no risk of tendinitis. Clinical studies have confirmed its effectiveness for treating respiratory tract infections, urinary tract infections, and other nosologies. Experts recommend the introduction of pazufloxacin into clinical practice, especially for patients at risk of developing cardiovascular complications and central nervous system lesions. It is also proposed to conduct post-registration studies to assess the effectiveness and safety of the drug in the Russian population and consider including it in the list of vital and essential drugs.