Modern approaches to improving the eff ectiveness of antibiotic therapy in perinatology: local experience

Premature newborns are group of high risk on development of infectious complications therefore the choice of effective and safe antibacterial therapy is relevant for them. In clinical practice treatment is complicated by the lack of data on sensitivity of bacterial cultures to antibacterial agents and the absence of accurate diagnostic markers, which are determined by blood tests or other laboratory tests. In order to determine the most rational and effective prescription of antibacterial therapy for premature newborns with infection of early neonatal sepsis, as well as for pregnant women at risk of prenatal outflow of amniotic fluid in preterm pregnancy, we analyzed the database of the perinatal center of ССР №24 with the data on prevalence and resistance of infectious agents among newborns and pregnant women. Taking into account the prevalence and sensitivity to the agents clinical protocol for the management of preterm birth and premature rupture of membranes with preterm pregnancy and recommendations for the treatment of early neonatal sepsis in newborns were compiled.

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