Амлодипин: обзор клинических исследований
Abstract
Амлодипин - антагонист кальциевых каналов дигидропиридинового ряда третьего поколения, блокирует медленные кальциевые каналы (каналы L-типа) и препятствует внутриклеточной гиперкальциемии и сокращению гладкомышечной клетки, оказывая сосудорасширяющее действие. Амлодипин обладает длительным действием, что позволяет применять его один раз в сутки. Амлодипин эффективно снижает артериальное давление, не влияя на частоту сокращений сердца у пациентов с артериальной гипертензией. Применяется также в лечении пациентов со стенокардией напряжения, в том числе эффективен при выраженном вазоспастическом компоненте ишемии. Препарат хорошо переносится, вызывая небольшое количество побочных эффектов. Применяется в комбинации с другими антиангинальными и антигипертензивными препаратами.
About the Authors
Н. Фельдшерова
НИИ кардиологии МЗ РФ, г. Санкт-Петербург
Russian Federation
Russian Federation
Е. Семернин
НИИ кардиологии МЗ РФ, г. Санкт-Петербург
Russian Federation
Russian Federation
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Review
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, . Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice. 2002;(2):27-33. (In Russ.)
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