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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinvest</journal-id><journal-title-group><journal-title xml:lang="ru">Качественная клиническая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0519</issn><issn pub-type="epub">2618-8473</issn><publisher><publisher-name>ООО «Издательство ОКИ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37489/2588-0519-2024-2-51-64</article-id><article-id custom-type="edn" pub-id-type="custom">RROUYQ</article-id><article-id custom-type="elpub" pub-id-type="custom">clinvest-717</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БЕЗОПАСНОСТЬ ЛЕКАРСТВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DRUG SAFETY</subject></subj-group></article-categories><title-group><article-title>Мониторинг и оценка безопасности межлекарственных взаимодействий у пациентов пожилого возраста</article-title><trans-title-group xml:lang="en"><trans-title>Monitoring and safety assessment of drug-drug interactions in elderly patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0955-095X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шараева</surname><given-names>А. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharaeva</surname><given-names>A. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шараева Айнура Турумбековна - к. м. н., доцент</p><p>Бишкек</p></bio><bio xml:lang="en"><p>Ainura T. Sharaeva - PhD, Cand. Sci. (Med.), Assistant Professor</p><p>Bishkek</p></bio><email xlink:type="simple">sharaeva75@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7093-981X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зурдинова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zurdinova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зурдинова Аида Аширалиевна - д. м. н., доцент</p><p>Бишкек</p></bio><bio xml:lang="en"><p>Aida A. Zurdinova - Dr. Sci. (Med.), Assistant Professor</p><p>Bishkek</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сатыбалдиева</surname><given-names>А. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Satybaldieva</surname><given-names>A. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сатыбалдиева Аида Токоновна - аспирант 4‑го года обучения</p><p>Бишкек</p></bio><bio xml:lang="en"><p>Aida T. Satybaldieva - 4th year PhD student</p><p>Bishkek</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГОУ ВПО «Кыргызско-Российский Славянский Университет имени первого Президента Российской Федерации Б. Н. Ельцина»</institution><country>Кыргызстан</country></aff><aff xml:lang="en"><institution>Kyrgyz Russian Slavic University named after First President of Russia B. N. Yeltsin</institution><country>Kyrgyzstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>25</day><month>06</month><year>2024</year></pub-date><volume>0</volume><issue>2</issue><fpage>52</fpage><lpage>65</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шараева А.Т., Зурдинова А.А., Сатыбалдиева А.Т., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Шараева А.Т., Зурдинова А.А., Сатыбалдиева А.Т.</copyright-holder><copyright-holder xml:lang="en">Sharaeva A.T., Zurdinova A.A., Satybaldieva A.T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinvest.ru/jour/article/view/717">https://www.clinvest.ru/jour/article/view/717</self-uri><abstract><p>Подавляющее большинство пожилых пациентов являются полиморбидными, чаще болеют и больше нуждаются в медицинском обеспечении. Каждое из имеющихся заболеваний требует постоянной лекарственной терапии, вследствие чего возрастает риск развития нежелательных лекарственных реакций от принимаемых препаратов. Также необходимо учесть, что пожилые пациенты более чувствительны к возникновению серьёзных нежелательных лекарственных реакций и взаимодействий.</p></abstract><trans-abstract xml:lang="en"><p>Most elderly patients have polymorbidity, have more frequent illnesses, and greater medical care needs. Each of the existing diseases requires constant drug therapy, thus increasing the risk of developing adverse drug reactions from the medications taken. It is also necessary to consider that elderly patients are more susceptible to the occurrence of serious adverse drug reactions and drug-drug interactions.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фармакотерапия</kwd><kwd>пожилые пациенты</kwd><kwd>нежелательные лекарственные реакции</kwd><kwd>фармакоэпидемиологический анализ</kwd><kwd>межлекарственные взаимодействия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pharmacotherapy</kwd><kwd>elderly patients</kwd><kwd>adverse drug reactions</kwd><kwd>pharmacoepidemiological analysis</kwd><kwd>drug-drug interactions</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">J. Mark Ruscin, Sunny A. Linnebur. Обзор медикаментозной терапии в пожилом возрасте. Справочник MSD, 2021.</mixed-citation><mixed-citation xml:lang="en">J. Mark Ruscin, Sunny A. Linnebur. Overview of Drug Therapy in Older Adults. MSD Manua. 2021. (In Russ.). Доступно по: https://clck.ru/3AxQ5v. Ссылка активна на 14.04.2024.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Rubin Bressler, Joseph J Bahl. Principles of drug therapy for the elderly patient. Mayo Clin Proc. 2003 Dec;78(12):1564-77. doi: 10.4065/78.12.1564.</mixed-citation><mixed-citation xml:lang="en">Rubin Bressler, Joseph J Bahl. Principles of drug therapy for the elderly patient. Mayo Clin Proc. 2003 Dec;78(12):1564-77. doi: 10.4065/78.12.1564.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Timothy W. Cutler, Thomas R. Clark. General Principles of Geriatric Drug Therapy. Journal of Contemporary Pharmacy Practice. 2018;65(1):31-35. doi: 10.37901/jcphp16-00025</mixed-citation><mixed-citation xml:lang="en">Timothy W. Cutler, Thomas R. Clark. General Principles of Geriatric Drug Therapy. Journal of Contemporary Pharmacy Practice. 2018;65(1):31-35. doi: 10.37901/jcphp16-00025</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Rochon PA, Gurwitz JH. Optimising drug treatment for elderly people: the prescribing cascade. BMJ. 1997 Oct 25;315(7115):1096-9. doi: 10.1136/bmj.315.7115.1096.</mixed-citation><mixed-citation xml:lang="en">Rochon PA, Gurwitz JH. Optimising drug treatment for elderly people: the prescribing cascade. BMJ. 1997 Oct 25;315(7115):1096-9. doi: 10.1136/bmj.315.7115.1096.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Gören Z, J Demirkapu M, Akpinar Acet G, et al. Potential drug-drug interactions among prescriptionsfor elderly patients in primary health care. Turk J Med Sci. 2017 Feb 27;47(1):47-54. doi: 10.3906/sag-1509-89.</mixed-citation><mixed-citation xml:lang="en">Gören Z, J Demirkapu M, Akpinar Acet G, et al. Potential drug-drug interactions among prescriptionsfor elderly patients in primary health care. Turk J Med Sci. 2017 Feb 27;47(1):47-54. doi: 10.3906/sag-1509-89.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Reichel W, Arenson C, Busby-Whitehead J. Essential principles in the care of the elderly. In: Busby-Whitehead J, Arenson C, Durso SC, et al., eds. Reichel’s Care of the Elderly Clinical Aspects of Aging. Cambridge University Press. 2016:1-16. doi: 10.1017/CBO9781107294967.001. Доступно по: https://clck.ru/3AxQrn. Ссылка активна на 15.04.2024.</mixed-citation><mixed-citation xml:lang="en">Reichel W, Arenson C, Busby-Whitehead J. Essential principles in the care of the elderly. In: Busby-Whitehead J, Arenson C, Durso SC, et al., eds. Reichel’s Care of the Elderly Clinical Aspects of Aging. Cambridge University Press. 2016:1-16. doi: 10.1017/CBO9781107294967.001. Доступно по: https://clck.ru/3AxQrn. Ссылка активна на 15.04.2024.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Luciana Mello de Oliveira, Juliana do Amaral Carneiro Diel, Alessandra Nunes, Tatiane da Silva Dal Pizzol. Prevalence of drug interactions in hospitalized elderly patients: a systematic review. European Journal of Hospital Pharmacy. 2019;28(1). doi: 10.1136/ejhpharm-2019-002111.</mixed-citation><mixed-citation xml:lang="en">Luciana Mello de Oliveira, Juliana do Amaral Carneiro Diel, Alessandra Nunes, Tatiane da Silva Dal Pizzol. Prevalence of drug interactions in hospitalized elderly patients: a systematic review. European Journal of Hospital Pharmacy. 2019;28(1). doi: 10.1136/ejhpharm-2019-002111.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bories M, Bouzillé G, Cuggia M, Le Corre P. Drug-Drug Interactions in Elderly Patients with Potentially Inappropriate Medications in Primary Care, Nursing Home and Hospital Settings: A Systematic Review and a Preliminary Study. Pharmaceutics. 2021 Feb 16;13(2):266. doi: 10.3390/pharmaceutics13020266.</mixed-citation><mixed-citation xml:lang="en">Bories M, Bouzillé G, Cuggia M, Le Corre P. Drug-Drug Interactions in Elderly Patients with Potentially Inappropriate Medications in Primary Care, Nursing Home and Hospital Settings: A Systematic Review and a Preliminary Study. Pharmaceutics. 2021 Feb 16;13(2):266. doi: 10.3390/pharmaceutics13020266.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Rochon P.A., Schmader K.E., Givens J. Drug prescribing for older adults, 2021. Available at: https://www.uptodate.com/contents/drug-prescribingfor-older-adults. Accessed Apr 15, 2024.</mixed-citation><mixed-citation xml:lang="en">Rochon P.A., Schmader K.E., Givens J. Drug prescribing for older adults, 2021. Available at: https://www.uptodate.com/contents/drug-prescribingfor-older-adults. Accessed Apr 15, 2024.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Краснова Н.М., Александрова Т.Н., Сеялова А.С. Оценка межлекарственных взаимодействий у пожилых пациентов в условиях коморбидности. Дальневосточный медицинский журнал. 2018;(1)23-25.</mixed-citation><mixed-citation xml:lang="en">Krasnova NM, Aleksandrova TN, Seyalova AS. Estimation of drug interactions in elderly patients with comorbidity. Far Eastern Medical Journal. 2018;(1)23-25. (In Russ.). Доступно по: http://eport.fesmu.ru/dmj/20181/2018104.aspx. Ссылка активна на 10.04.2024.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Полипрагмазия в клинической практике: проблема и решения: учебное пособие / Д.А. Сычев ГБОУ ДПО «Российская медицинская академия последипломного образования». — М.: ГБОУ ДПО РМАПО, 2016. — 249с.</mixed-citation><mixed-citation xml:lang="en">Polypragmasia in clinical practice: problem and solutions: textbook / D.A. Sychev GBOU DPO "Russian Medical Academy of Postgraduate Education". — M.: GBOU DPO RMAPO, 2016. (In Russ.). ISBN 978-5-7249-2542-6. Доступно по: https://clck.ru/3AxTUc. Ссылка активна на 15.04.2024.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Яковлев А.А. Факторы риска полипрагмазии у лиц старших возрастных групп с хронической сердечной недостаточностью. Научно-практический рецензируемый журнал "Современные проблемы здравоохранения и медицинской статистики". 2021;(4):262-285.</mixed-citation><mixed-citation xml:lang="en">Yakovlev АА. Risk factors for polypragmasia in older age groups with chronic heart failure. Scientific journal "Current problems of health care and medical statistics". 2021;(4):262-285. (In Russ.). doi: 10.24412/2312-2935-2021-4-262-285.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ибышева А.Т., Мулдаева Г.М., Арыстан Л.И., и др. Полиморбидность и полипрагмазия у пожилых лиц на уровне первичного звена. Международный журнал прикладных и фундаментальных исследований. 2021;(5):12-16.</mixed-citation><mixed-citation xml:lang="en">Ibysheva AT, Muldaeva GM, Arystan LI, et al. The multimorbidity and polypharmacy in the older people in the primary care. International journal of applied and fundamental research. 2021;(5):12-16. (In Russ.). Доступно по: https://clck.ru/3AxaWF. Ссылка активна на 30.05.2024.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Шараева А.Т., Зурдинова А.А. Проблемы полипрагмазии в гериатрической практике Кыргызской Республики. Качественная клиническая практика. 2022;(3):52-61.</mixed-citation><mixed-citation xml:lang="en">Sharaeva AT, Zurdinova AA. Polypharmacy problems in geriatric practice of Kyrgyz Republic. Kachestvennaya klinicheskaya praktika = Good Clinical Practice. 2022;(3):52-61. (In Russ.). doi: 10.37489/2588-0519-2022-3-52-61.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
