clinvestКачественная клиническая практикаKachestvennaya Klinicheskaya Praktika = Good Clinical Practice2588-05192618-8473ООО «Издательство ОКИ10.37489/2588-0519-2020-S4-23-27clinvest-520Research ArticleАКТУАЛЬНЫЕ ОБЗОРЫACTUAL REVIEWМесто метилпреднизолона в лечении острого респираторного дистресс-синдрома у пациентов с COVID-19: целесообразность применения, оптимальные схемы дозирования, сочетание с введением тоцилизумабаMethylprednisolone in acute respiratory distress-syndrome in COVID-19: rationales for use, optimal dosage regimens, combined use with tocilizumabhttps://orcid.org/0000-0002-9307-4994МирзаевК. Б.MirzaevK. B.

Мирзаев Карин Бадавиевич – к. м. н., доцент кафедры клинической фармакологии и терапии. SPIN-код: 8308-7599

Москва

Mirzaev Karin B. – Candidate of Medical Sciences, Associate Professor of the Department of Clinical Pharmacology and Therapy. SPIN code: 8308-7599

Moscow

https://orcid.org/0000-0002-6753-8572КиселёвЮ. Ю.KiselevYu. Yu.

Киселёв Юрий Юрьевич – PhD, доцент факультета наук о здоровье OsloMet.

Осло

Kiselev Yuri Yu. – PhD, Associate Professor at the Faculty of Health Sciences OsloMet.

Oslo

https://orcid.org/0000-0002-4496-3680СычёвД. А.SychevD. A.

Сычёв Дмитрий Алексеевич – д. м. н., профессор, член-корр. РАН, ректор, зав. кафедрой клинической фармакологии и терапии. SPIN-код: 4525-7556

Москва

Sychev Dmitry A. – Doctor of Medical Sciences, Professor, Corresponding Member RAS, Rector, Head. Department of Clinical Pharmacology and Therapy. SPIN code: 4525-7556

Moscow

dmitriy.alex.sychev@gmail.comФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияRussian Medical Academy of Continuing Professional Education of the Ministry of Health of RussiaRussian FederationУниверситет Осло МетрополитенНорвегияOslo Metropolitan UniversityNorway20202710202004SФармаCOVID2327Copyright © Мирзаев К.Б., Киселёв Ю.Ю., Сычёв Д.А., 20202020Мирзаев К.Б., Киселёв Ю.Ю., Сычёв Д.А.Mirzaev K.B., Kiselev Y.Y., Sychev D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.clinvest.ru/jour/article/view/520

Не обнаружено убедительных данных касательно клинической эффективности метилпреднизолона у пациентов с острым респираторным дистресс-синдромом при COVID-19, в том числе в сочетании с тоцилизумабом. У таких пациентов допустимо назначение системных глюкокортикостероидов по жизненным показаниям при отсутствии блокаторов рецепторов IL-6 (тоцилизумаб, сарилумаб).

No robust evidence proving clinical effectiveness of methylprednisolone in acute respiratory distress-syndrome in COVID-19, including combined use with tocilizumab, has been identified. Systemic glucocorticosteroids use may be considered acceptable in such patients in life-threatening situations, when interleukin-6 blockers (tocilizumab, sarilumab) are unavailable.

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The authors declare that there are no conflicts of interest present.