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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinvest</journal-id><journal-title-group><journal-title xml:lang="ru">Качественная клиническая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0519</issn><issn pub-type="epub">2618-8473</issn><publisher><publisher-name>ООО «Издательство ОКИ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.37489/2588-0519-2020-S4-8-10</article-id><article-id custom-type="elpub" pub-id-type="custom">clinvest-516</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL REVIEW</subject></subj-group></article-categories><title-group><article-title>Возможность применения бромгексина для профилактики инфицирования SARS-CoV-2</article-title><trans-title-group xml:lang="en"><trans-title>Possibility for the use of bromhexine to prevent infection with SARS-CoV-2</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5251-5319</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Загородникова</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zagorodnikova</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Загородникова Ксения Александровна – к. м. н., PhD, зав. отделом клинической фармакологии. SPIN-код: 4669-2059</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Zagorodnikova Ksenia A. – Candidate of Medical Sciences, PhD, Head of the Department of Clinical Pharmacology. SPIN code: 4669-2059</p><p>St. Petersburg</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9307-4994</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мирзаев</surname><given-names>К. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Mirzaev</surname><given-names>K. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мирзаев Карин Бадавиевич – к. м. н., доцент кафедры клинической фармакологии и терапии. SPIN-код: 8308-7599</p><p>Москва</p></bio><bio xml:lang="en"><p>Mirzaev Karin B. – Candidate of Medical Sciences, Associate Professor of the Department of Clinical Pharmacology. SPIN code: 8308-7599</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4496-3680</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сычёв</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sychev</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сычёв Дмитрий Алексеевич – д. м. н., профессор, член-корр. РАН, ректор, зав. кафедрой клинической фармакологии и терапии. SPIN-код: 4525-7556</p><p>Москва</p></bio><bio xml:lang="en"><p>Sychev Dmitry A. – Doctor of Medical Sciences, Professor, Corresponding Member RAS, Rector, Head. Department of Clinical Pharmacology and Therapy. SPIN code: 4525-7556</p><p>Moscow</p></bio><email xlink:type="simple">dmitriy.alex.sychev@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр имени В. А. Алмазова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center named after V.A. Almazov of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>27</day><month>10</month><year>2020</year></pub-date><volume>0</volume><issue>4S</issue><issue-title>ФармаCOVID</issue-title><fpage>8</fpage><lpage>10</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Загородникова К.А., Мирзаев К.Б., Сычёв Д.А., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Загородникова К.А., Мирзаев К.Б., Сычёв Д.А.</copyright-holder><copyright-holder xml:lang="en">Zagorodnikova K.A., Mirzaev K.B., Sychev D.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinvest.ru/jour/article/view/516">https://www.clinvest.ru/jour/article/view/516</self-uri><abstract><p>Рутинное применение препарата бромгексин для профилактики инфицирования SARS-CoV-2 не рекомендуется. Применение бромгексина возможно только в рамках клинических исследований.</p></abstract><trans-abstract xml:lang="en"><p>The routine use of bromhexine to prevent infection SARS-CoV-2 is not recommended. The use of bromhexine is possible in clinical trials.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>коронавирус</kwd><kwd>бромгексин</kwd><kwd>COVID-19</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronavirus</kwd><kwd>bromhexine</kwd><kwd>COVID-19</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ishiguro N, Senda C, Kishimoto W, Sakai K, Funae Y, Igarashi T. Identification of CYP3A4 as the predominant isoform responsible for the metabolism of ambroxol in human liver microsomes. Xenobiotica. 2000;30(1):71-80. DOI:10.1080/004982500237839</mixed-citation><mixed-citation xml:lang="en">Ishiguro N, Senda C, Kishimoto W, Sakai K, Funae Y, Igarashi T. 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