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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinvest</journal-id><journal-title-group><journal-title xml:lang="ru">Качественная клиническая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0519</issn><issn pub-type="epub">2618-8473</issn><publisher><publisher-name>ООО «Издательство ОКИ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24411/2588-0519-2019-10077</article-id><article-id custom-type="elpub" pub-id-type="custom">clinvest-456</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НОВЫЕ ЛЕКАРСТВЕННЫЕ СРЕДСТВА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEW DRUGS AND HEALTH TECHNOLOGIES</subject></subj-group></article-categories><title-group><article-title>Инновационные лекарственные препараты для терапии первичных головных болей: мигрень</article-title><trans-title-group xml:lang="en"><trans-title>Innovative drugs for the treatment of primary headaches: migraine</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3107-7636</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Решетько</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Reshetko</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Решетько Ольга Вилоровна Автор – доктор медицинских наук профессор, заведующий кафедрой фармакологии</p><p>SPIN-код: 7569-7915</p></bio><bio xml:lang="en"><p>Reshetko Olga - MD, professor, Head of Department of Pharmacology</p><p>SPIN-code: 7569-7915</p></bio><email xlink:type="simple">reshetko@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гришин</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Grishin</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гришин Антон Игоревич - аспирант кафедры фармакологии</p></bio><bio xml:lang="en"><p>Grishin Anton - Post-graduate student, Department of Pharmacology</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Саратовский государственный медицинский университет им. В.И. Разумовского» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saratov State Medical University named after VI. Razumovskiy of the Health Ministry of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>22</day><month>10</month><year>2019</year></pub-date><volume>0</volume><issue>2</issue><fpage>95</fpage><lpage>104</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Решетько О.В., Гришин А.И., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Решетько О.В., Гришин А.И.</copyright-holder><copyright-holder xml:lang="en">Reshetko O.V., Grishin A.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinvest.ru/jour/article/view/456">https://www.clinvest.ru/jour/article/view/456</self-uri><abstract/><trans-abstract xml:lang="en"><p>The article presents information about innovative drugs for the treatment of primary headaches (in particular, migraine), which are at the stages of clinical or preclinical studies, or were recently introduced to the foreign pharmaceutical market. The classes of these drugs, their mechanism of action, as well as the results of past studies are presents in article.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мигрень</kwd><kwd>противомигренозные лекарственные препараты</kwd><kwd>первичные головные боли</kwd><kwd>кальцито-нин-ген-связанный пептид</kwd><kwd>боль</kwd><kwd>PACAP3</kwd><kwd>5-HT1F</kwd></kwd-group><kwd-group xml:lang="en"><kwd>migraine</kwd><kwd>antimigraine drugs</kwd><kwd>primary headaches</kwd><kwd>calcitonin-gene-related peptide (GCRP)</kwd><kwd>pain</kwd><kwd>PACAP3</kwd><kwd>5-HT1</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">who.int [интернет]. Всемирная Организация Здравоохранения. Информационный бюллетень Всемирной Организации Здравоохранения “Головные боли”, 2016 [доступ от 7.05.2019]. 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