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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinvest</journal-id><journal-title-group><journal-title xml:lang="ru">Качественная клиническая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0519</issn><issn pub-type="epub">2618-8473</issn><publisher><publisher-name>ООО «Издательство ОКИ</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">clinvest-362</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БЕЗОПАСНОСТЬ ЛЕКАРСТВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DRUG SAFETY</subject></subj-group></article-categories><title-group><article-title>Полипрагмазия и лекарственные взаимодействия у пожилых пациентов</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Манешина</surname><given-names>О. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра клинической фармакологии с курсом фармакокинетики ФУВ</p></bio><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белоусов</surname><given-names>Ю. Б.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф., зав. кафедрой клинической фармакологии с курсом фармакокинетики ФУВ</p></bio><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Российский государственный медицинский университет, г. Москва</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ГОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова», Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>29</day><month>06</month><year>2018</year></pub-date><volume>0</volume><issue>3</issue><fpage>90</fpage><lpage>93</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Манешина О.А., Белоусов Ю.Б., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Манешина О.А., Белоусов Ю.Б.</copyright-holder><copyright-holder xml:lang="en">Манешина О.А., Белоусов Ю.Б.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinvest.ru/jour/article/view/362">https://www.clinvest.ru/jour/article/view/362</self-uri><abstract><p>Известно, что около 80% пожилых людей страдают хроническими заболеваниями. Пожилые люди чаще болеют, имеют, как правило, не одно хроническое заболевание и чаще нуждаются в медицинском обеспечении. В случае, когда каждое из имеющихся заболеваний требует постоянной лекарственной терапии, в несколько раз возрастает риск развития неблагоприятных эффектов от принимаемых препаратов. Кроме того, пожилые пациенты более чувствительны к возникновению серьезных нежелательных явлений и лекарственных взаимодействий.</p></abstract><kwd-group xml:lang="ru"><kwd>безопасность лекарств</kwd><kwd>нежелательные явления</kwd><kwd>лекарственное взаимодействие</kwd><kwd>пожилые пациенты</kwd><kwd>полипрагмазия</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Jackson, D.M. and Soothill, R., Is the Medictne Making You ill?, North Ryde, Australia, Angus &amp; Robeitson, 1989, px.</mixed-citation><mixed-citation xml:lang="en">Jackson, D.M. and Soothill, R., Is the Medictne Making You ill?, North Ryde, Australia, Angus &amp; Robeitson, 1989, px.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Эндрю Четли. Проблемные лекарства</mixed-citation><mixed-citation xml:lang="en">Эндрю Четли. 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