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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinvest</journal-id><journal-title-group><journal-title xml:lang="ru">Качественная клиническая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0519</issn><issn pub-type="epub">2618-8473</issn><publisher><publisher-name>ООО «Издательство ОКИ</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">clinvest-338</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICAL RECOMMENDATIONS</subject></subj-group></article-categories><title-group><article-title>Практические подходы к применению гепарина при сердечно-сосудистых заболеваниях</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Явелов</surname><given-names>И. С.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра клинической фармакологии с курсом клинической фармакологии и фармакокинетики ФУВ</p></bio><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБУ «НМИЦ профилактической медицины» МЗ РФ; ФГБОУ ВО «РНИМУ им. Н.И. Пирогова» МЗ РФ</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>27</day><month>06</month><year>2018</year></pub-date><volume>0</volume><issue>2</issue><fpage>88</fpage><lpage>92</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Явелов И.С., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Явелов И.С.</copyright-holder><copyright-holder xml:lang="en">Явелов И.С.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinvest.ru/jour/article/view/338">https://www.clinvest.ru/jour/article/view/338</self-uri><abstract><p>В статье дается описание действия низкомолекулярных и нефракционированных гепаринов, их клиническая эффективность, принципы дозирования, противопоказания и лекарственные взаимодействия.</p></abstract><kwd-group xml:lang="ru"><kwd>низкомолекулярные гепарины</kwd><kwd>нефракционированные гепарины</kwd><kwd>сердечно-сосудистые заболевания</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hirsh J., Raschke R. 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