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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinvest</journal-id><journal-title-group><journal-title xml:lang="ru">Качественная клиническая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0519</issn><issn pub-type="epub">2618-8473</issn><publisher><publisher-name>ООО «Издательство ОКИ</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">clinvest-262</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НОВЫЕ ЛЕКАРСТВЕННЫЕ СРЕДСТВА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEW DRUGS AND HEALTH TECHNOLOGIES</subject></subj-group></article-categories><title-group><article-title>Линезолид - первый препарат нового класса антибактериальных средств оксазолидинонов</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефременкова</surname><given-names>О. В.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра клинической фармакологии</p></bio><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белоусов</surname><given-names>Ю. Б.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф., зав. кафедрой клинической фармакологии</p></bio><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова», Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2002</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2008</year></pub-date><volume>0</volume><issue>2</issue><fpage>2</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ефременкова О.В., Белоусов Ю.Б., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Ефременкова О.В., Белоусов Ю.Б.</copyright-holder><copyright-holder xml:lang="en">Ефременкова О.В., Белоусов Ю.Б.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinvest.ru/jour/article/view/262">https://www.clinvest.ru/jour/article/view/262</self-uri><abstract><p>В статье описан новый класс антибактериальных препаратов - оксазолидинонов, среди который первый - линезолид - эффективный препарат для лечения MRSA-инфекции.</p></abstract><kwd-group xml:lang="ru"><kwd>линезолид</kwd><kwd>антибактериальные средства</kwd><kwd>оксазолидиноны</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Norrby R. Linezolid - a review of the first oxazolidinone. Exp Opin Pharmacother 2001; 2(2): 93-302.</mixed-citation><mixed-citation xml:lang="en">Norrby R. Linezolid - a review of the first oxazolidinone. Exp Opin Pharmacother 2001; 2(2): 93-302.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Diekema DJ, Jones RN. Oxazolidinone antibiotics. Lancet 2001; 358:1975-82.</mixed-citation><mixed-citation xml:lang="en">Diekema DJ, Jones RN. Oxazolidinone antibiotics. Lancet 2001; 358:1975-82.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Brickner SJ, Hutchinson DK, Barbachyn MR et al. Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment</mixed-citation><mixed-citation xml:lang="en">Brickner SJ, Hutchinson DK, Barbachyn MR et al. Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">of multi-drug resistant Gram-positive bacterial infections. J Med Chem 1996; 39:673-679.</mixed-citation><mixed-citation xml:lang="en">of multi-drug resistant Gram-positive bacterial infections. J Med Chem 1996; 39:673-679.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Shinabarger DL, Marotti KR, Murray RW et al. Mechanism of action of the oxazolidinones: effects of linezolid and eperezolid on translation reactions. Antimicrob Agents</mixed-citation><mixed-citation xml:lang="en">Shinabarger DL, Marotti KR, Murray RW et al. Mechanism of action of the oxazolidinones: effects of linezolid and eperezolid on translation reactions. Antimicrob Agents</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chemother 1997; 41:2132-2136.</mixed-citation><mixed-citation xml:lang="en">Chemother 1997; 41:2132-2136.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Jones RN, Johson DM, Erwin ME. In vitro antimicrobial activities and spectra of U-100592 and U-100766 two novel fluorinated oxazolidinones. Antimicrob Agents</mixed-citation><mixed-citation xml:lang="en">Jones RN, Johson DM, Erwin ME. In vitro antimicrobial activities and spectra of U-100592 and U-100766 two novel fluorinated oxazolidinones. Antimicrob Agents</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Chemother 1996; 40:720-726.</mixed-citation><mixed-citation xml:lang="en">Chemother 1996; 40:720-726.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zurenko GE, Yagi BH, Schaadt RD et al. In vitro activities of U-100592 and U-100766, novel îxazolidinone antibacterial agents. Antimicrob Agents Chemother 1996; 40:839-845.</mixed-citation><mixed-citation xml:lang="en">Zurenko GE, Yagi BH, Schaadt RD et al. In vitro activities of U-100592 and U-100766, novel îxazolidinone antibacterial agents. Antimicrob Agents Chemother 1996; 40:839-845.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Jorgensen JH, McElmeel ML, Trippy CW. In vitro activities of the oxazolidinones U-100592 and U-100766 against Staphylococcus aureus and coagulase-negative</mixed-citation><mixed-citation xml:lang="en">Jorgensen JH, McElmeel ML, Trippy CW. In vitro activities of the oxazolidinones U-100592 and U-100766 against Staphylococcus aureus and coagulase-negative</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Staphylococcus species. Antimicrob Agents Chemother 1997; 41:465-467.</mixed-citation><mixed-citation xml:lang="en">Staphylococcus species. Antimicrob Agents Chemother 1997; 41:465-467.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Goldtsein EJC, Citron DM, Meeriam CV. Linezolid activity compared to those of selected macrolides and other agents against aerobic and anaerobic pathogens isolated from soft</mixed-citation><mixed-citation xml:lang="en">Goldtsein EJC, Citron DM, Meeriam CV. Linezolid activity compared to those of selected macrolides and other agents against aerobic and anaerobic pathogens isolated from soft</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">tissue bite infections in humans. Antimicrob Agents Chemother 1999; 43:1469-1474.</mixed-citation><mixed-citation xml:lang="en">tissue bite infections in humans. Antimicrob Agents Chemother 1999; 43:1469-1474.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Wise R, Andrews JM, Boswell FJ et al. The in-vitro activity of linezolid and tentative breakpoints. J Antimicrob Chemother 1998; 42:721-728.</mixed-citation><mixed-citation xml:lang="en">Wise R, Andrews JM, Boswell FJ et al. The in-vitro activity of linezolid and tentative breakpoints. J Antimicrob Chemother 1998; 42:721-728.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Mason EO, Jr., Lamberth LB, Kaplan SL. In vitro activities of oxazolidinones U-100592 and U-100766 against penicillin-resistant and cephalosporin-resistant strains</mixed-citation><mixed-citation xml:lang="en">Mason EO, Jr., Lamberth LB, Kaplan SL. In vitro activities of oxazolidinones U-100592 and U-100766 against penicillin-resistant and cephalosporin-resistant strains</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">of Streptococcus pneumoniae. Antimicrob Agents Chemother 1996; 40:1039-1040.</mixed-citation><mixed-citation xml:lang="en">of Streptococcus pneumoniae. Antimicrob Agents Chemother 1996; 40:1039-1040.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Eliopulos GM, Wennersten CB, Gold HS et al. In vitro activities of new oxazolidinones antimicrobial agents against enterococci. Antimicrob Agents Chemother 1996; 40:1745-1747.</mixed-citation><mixed-citation xml:lang="en">Eliopulos GM, Wennersten CB, Gold HS et al. In vitro activities of new oxazolidinones antimicrobial agents against enterococci. Antimicrob Agents Chemother 1996; 40:1745-1747.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kaatz GW, Seo SM. In vitro activities of oxazolidinone compounds U100592 and U100766 against Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents</mixed-citation><mixed-citation xml:lang="en">Kaatz GW, Seo SM. In vitro activities of oxazolidinone compounds U100592 and U100766 against Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Chemother 1996; 40:799-801.</mixed-citation><mixed-citation xml:lang="en">Chemother 1996; 40:799-801.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Rybak MJ, Cappelletty DM, Moldovan T et al. Comparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid</mixed-citation><mixed-citation xml:lang="en">Rybak MJ, Cappelletty DM, Moldovan T et al. Comparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">(PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, and Enterococcus faecium. Antimicrob Agents</mixed-citation><mixed-citation xml:lang="en">(PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, and Enterococcus faecium. Antimicrob Agents</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Chemother 1998; 42:721-724.</mixed-citation><mixed-citation xml:lang="en">Chemother 1998; 42:721-724.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Noskin GA, Siddiqui F, Stosor V et al. In vitro activities of linezolid against important Gram-positive bacterial patogens including vancomycin-resistant enterococci.</mixed-citation><mixed-citation xml:lang="en">Noskin GA, Siddiqui F, Stosor V et al. In vitro activities of linezolid against important Gram-positive bacterial patogens including vancomycin-resistant enterococci.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Antimicrob Agents Chemother 1999; 43: 2059-2062.</mixed-citation><mixed-citation xml:lang="en">Antimicrob Agents Chemother 1999; 43: 2059-2062.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Rybak MJ,,Hershberger E, Moldovan T et al. In vitro activities of daptomycin, vancomycin, linezolid and quinopristin-dalfopristin against staphylococci and enterococci,</mixed-citation><mixed-citation xml:lang="en">Rybak MJ,,Hershberger E, Moldovan T et al. In vitro activities of daptomycin, vancomycin, linezolid and quinopristin-dalfopristin against staphylococci and enterococci,</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">including vancomycin-intermediate and strains. Antimicrob Agents Chemother 2000; 44:1062-1066.</mixed-citation><mixed-citation xml:lang="en">including vancomycin-intermediate and strains. Antimicrob Agents Chemother 2000; 44:1062-1066.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Schülin T, Wenersten CB, Ferraro MJ et al. Susceptibilities of Legionella spp. to newer antimicrobial in vitro. Antimicrob Agents Chemother 1998; 42:1520-1523.</mixed-citation><mixed-citation xml:lang="en">Schülin T, Wenersten CB, Ferraro MJ et al. Susceptibilities of Legionella spp. to newer antimicrobial in vitro. Antimicrob Agents Chemother 1998; 42:1520-1523.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Marchese A, Schito GC. The oxazolidinones as a new family of antimicrobial agent. Clin Microbiol Infect 2001; 7 (Suppl. 4): 66-74.</mixed-citation><mixed-citation xml:lang="en">Marchese A, Schito GC. The oxazolidinones as a new family of antimicrobial agent. Clin Microbiol Infect 2001; 7 (Suppl. 4): 66-74.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Murray RW, Schaadt RD, Zurenko GE. Ribosomes from an oxazolidinone- resistant mutant confer resistance to eperezolid in a Staphylococcus aureus cell-free</mixed-citation><mixed-citation xml:lang="en">Murray RW, Schaadt RD, Zurenko GE. Ribosomes from an oxazolidinone- resistant mutant confer resistance to eperezolid in a Staphylococcus aureus cell-free</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">transcription-translation assay. Antimicrob Agents Chemother 1998; 42: 947-950.</mixed-citation><mixed-citation xml:lang="en">transcription-translation assay. Antimicrob Agents Chemother 1998; 42: 947-950.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Clemett D, Markham A. Linezolid. Drugs 2000; 59(4):815-827.</mixed-citation><mixed-citation xml:lang="en">Clemett D, Markham A. Linezolid. Drugs 2000; 59(4):815-827.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Cynamon MH, Klemens SP, Sharpe CA et al. Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model. Antimicrob Agents</mixed-citation><mixed-citation xml:lang="en">Cynamon MH, Klemens SP, Sharpe CA et al. Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model. Antimicrob Agents</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Chemother 1999; 43:1189-1191.</mixed-citation><mixed-citation xml:lang="en">Chemother 1999; 43:1189-1191.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Ford CW, Hamel JC, Wilson DM et al. In vivo activities of U-100592 and U-100766, novel îxazolidinone antimicrobial agents, against experimental bacterial infections.</mixed-citation><mixed-citation xml:lang="en">Ford CW, Hamel JC, Wilson DM et al. In vivo activities of U-100592 and U-100766, novel îxazolidinone antimicrobial agents, against experimental bacterial infections.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Antimicrob Agents Chemother 2000; 44: 1508-1613.</mixed-citation><mixed-citation xml:lang="en">Antimicrob Agents Chemother 2000; 44: 1508-1613.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Pelton SI, Figuera M, Albut R et al. Efficacy of linezolid in experimental otitis media. Antimicrob Agents Chemother 2000; 44: 654-657.</mixed-citation><mixed-citation xml:lang="en">Pelton SI, Figuera M, Albut R et al. Efficacy of linezolid in experimental otitis media. Antimicrob Agents Chemother 2000; 44: 654-657.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Diekema DJ, Jones RN. Oxazolidinones: a review. Drugs 2000; 59: 7-16.</mixed-citation><mixed-citation xml:lang="en">Diekema DJ, Jones RN. Oxazolidinones: a review. Drugs 2000; 59: 7-16.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Bouza E, Munoz P. Linezolid: pharmacokinetic characteristics and clinical studies. Clin Microbiol Infect 2001; 7 (Suppl. 4): 75-82.</mixed-citation><mixed-citation xml:lang="en">Bouza E, Munoz P. Linezolid: pharmacokinetic characteristics and clinical studies. Clin Microbiol Infect 2001; 7 (Suppl. 4): 75-82.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Herndershof PE, Jungbluth GL, Cammarata SK et al. Pharmacokinetics of linezolid in patients with liver disease. J Antimicrob Chemother 1999; 44(Suppl. A):55. Abstract.</mixed-citation><mixed-citation xml:lang="en">Herndershof PE, Jungbluth GL, Cammarata SK et al. Pharmacokinetics of linezolid in patients with liver disease. J Antimicrob Chemother 1999; 44(Suppl. A):55. Abstract.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Conte JE Jr, Golden JA, Kipps JE et al. Intrapulmonary pharmacokinetics of linezolid. The 40th ICAAC. Toronto, Canada 2000. Abstract No. 659.</mixed-citation><mixed-citation xml:lang="en">Conte JE Jr, Golden JA, Kipps JE et al. Intrapulmonary pharmacokinetics of linezolid. The 40th ICAAC. Toronto, Canada 2000. Abstract No. 659.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Molinari M, Mangano R, Gough M et al. Linezolid in the treatment of streptococcal skin and soft tissue infections: combined results from three Phase III trials. Clin Microbiol</mixed-citation><mixed-citation xml:lang="en">Molinari M, Mangano R, Gough M et al. Linezolid in the treatment of streptococcal skin and soft tissue infections: combined results from three Phase III trials. Clin Microbiol</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Infect 2000; 6(Suppl. 1):64. Abstract.</mixed-citation><mixed-citation xml:lang="en">Infect 2000; 6(Suppl. 1):64. Abstract.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Regazzi M.B. et al. Cerebrospinal fluid linezolid concentrations in postneurosurgical central nervous system infections. Antimicrob Agents Chemother 2002; 46: 936-937.</mixed-citation><mixed-citation xml:lang="en">Regazzi M.B. et al. Cerebrospinal fluid linezolid concentrations in postneurosurgical central nervous system infections. Antimicrob Agents Chemother 2002; 46: 936-937.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Duvall S, Bruss J, Todd W et al. Linezolid in the treatment of staphylococcal skin and soft tissue infections: combined results from three Phase III trials. Clin Microbiol</mixed-citation><mixed-citation xml:lang="en">Duvall S, Bruss J, Todd W et al. Linezolid in the treatment of staphylococcal skin and soft tissue infections: combined results from three Phase III trials. Clin Microbiol</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Infect 2000; 6(Suppl. 1):64. Abstract.</mixed-citation><mixed-citation xml:lang="en">Infect 2000; 6(Suppl. 1):64. Abstract.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Cammarata SK, San Pedro GS, Timm JA et al. Comparison of linezolid versus ceftriaxone/cefpodoxime in the treatment of hospitalized patients with community</mixed-citation><mixed-citation xml:lang="en">Cammarata SK, San Pedro GS, Timm JA et al. Comparison of linezolid versus ceftriaxone/cefpodoxime in the treatment of hospitalized patients with community</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">acquired pneumonia:European results. Clin Microbiol Infect 2000; 6(Suppl. 1):136. Abstract.</mixed-citation><mixed-citation xml:lang="en">acquired pneumonia:European results. Clin Microbiol Infect 2000; 6(Suppl. 1):136. Abstract.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Cammarata SK, Standford H, Todd WM et al. Linezolid eradicates common pathogens in community-acquired pneumonia. Clin Microbiol Infect 2000; 6(Suppl. 1):136. Abstract.</mixed-citation><mixed-citation xml:lang="en">Cammarata SK, Standford H, Todd WM et al. Linezolid eradicates common pathogens in community-acquired pneumonia. Clin Microbiol Infect 2000; 6(Suppl. 1):136. Abstract.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Stevens DL, Smith LG, Bruss JB et al. Randomized comparison of linezolid (PNU-100766) versus oxacillin-dicloxacillin for treatment of complicated skin and soft tissue</mixed-citation><mixed-citation xml:lang="en">Stevens DL, Smith LG, Bruss JB et al. Randomized comparison of linezolid (PNU-100766) versus oxacillin-dicloxacillin for treatment of complicated skin and soft tissue</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">infections. Antimicrob Agents Chemother 2000; 44: 3408-3413.</mixed-citation><mixed-citation xml:lang="en">infections. Antimicrob Agents Chemother 2000; 44: 3408-3413.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Rubinstein E, Cammarata SK, Oliphant T et al. Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia:</mixed-citation><mixed-citation xml:lang="en">Rubinstein E, Cammarata SK, Oliphant T et al. Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia:</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">a randomized, double-blind multicenter study. Clin Infect Dis 2001; 32: 402-412.</mixed-citation><mixed-citation xml:lang="en">a randomized, double-blind multicenter study. Clin Infect Dis 2001; 32: 402-412.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Cammarata SK, Le V, Oliphant TH et al. Incidence of Clostridium difficile related complications during clinical trials of linezolid, an oxazolidinone. The 40th ICAAC. Toronto,</mixed-citation><mixed-citation xml:lang="en">Cammarata SK, Le V, Oliphant TH et al. Incidence of Clostridium difficile related complications during clinical trials of linezolid, an oxazolidinone. The 40th ICAAC. Toronto,</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Canada 2000. Abstract 2132.</mixed-citation><mixed-citation xml:lang="en">Canada 2000. Abstract 2132.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
