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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinvest</journal-id><journal-title-group><journal-title xml:lang="ru">Качественная клиническая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0519</issn><issn pub-type="epub">2618-8473</issn><publisher><publisher-name>ООО «Издательство ОКИ</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">clinvest-258</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL TRIALS</subject></subj-group></article-categories><title-group><article-title>Многоцентровое исследование сравнительной эффективности режимов комбинированной терапии у пациентов с тяжелой неконтролируемой бронхиальной астмой</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Огородова</surname><given-names>Л. М.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кобякова</surname><given-names>О. С.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петровский</surname><given-names>Ф. И.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смоленов</surname><given-names>И. С.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ребров</surname><given-names>А. П.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пунин</surname><given-names>А. А.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скалозуб</surname><given-names>Е. А.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сметаненко</surname><given-names>Т. В.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кароли</surname><given-names>Н. А.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Деев</surname><given-names>И. А.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>Т. В.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Молотков</surname><given-names>А. О.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сосонная</surname><given-names>Н. А.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ханова</surname><given-names>Ф. М</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-8"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Сибирский государственный медицинский университет</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Волгоградская государственная медицинская академия</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>Саратовский государственный медицинский университет</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-4"><institution>Смоленская государственная медицинская академия</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-5"><institution>Алтайский государственный медицинский университет</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-6"><institution>Томская областная клиническая больница</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-7"><institution>Волгоградская медицинская академия</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-8"><institution>ГНЦ РФ институт иммунологии МЗ РФ</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2002</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2008</year></pub-date><volume>0</volume><issue>2</issue><fpage>18</fpage><lpage>26</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Огородова Л.М., Кобякова О.С., Петровский Ф.И., Смоленов И.С., Ребров А.П., Пунин А.А., Скалозуб Е.А., Сметаненко Т.В., Кароли Н.А., Деев И.А., Иванова Т.В., Молотков А.О., Сосонная Н.А., Ханова Ф.М., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Огородова Л.М., Кобякова О.С., Петровский Ф.И., Смоленов И.С., Ребров А.П., Пунин А.А., Скалозуб Е.А., Сметаненко Т.В., Кароли Н.А., Деев И.А., Иванова Т.В., Молотков А.О., Сосонная Н.А., Ханова Ф.М.</copyright-holder><copyright-holder xml:lang="en">Огородова Л.М., Кобякова О.С., Петровский Ф.И., Смоленов И.С., Ребров А.П., Пунин А.А., Скалозуб Е.А., Сметаненко Т.В., Кароли Н.А., Деев И.А., Иванова Т.В., Молотков А.О., Сосонная Н.А., Ханова Ф.М.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinvest.ru/jour/article/view/258">https://www.clinvest.ru/jour/article/view/258</self-uri><abstract><p>Отсутствие контроля на бронхиальной астмой является основной проблемой ведения пациентов.</p></abstract><kwd-group xml:lang="ru"><kwd>неконтролируемая бронхиальная астма</kwd><kwd>фенотип brittle</kwd><kwd>Серетид Мультидиск</kwd><kwd>клиническое исследование</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
