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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinvest</journal-id><journal-title-group><journal-title xml:lang="ru">Качественная клиническая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0519</issn><issn pub-type="epub">2618-8473</issn><publisher><publisher-name>ООО «Издательство ОКИ</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">clinvest-253</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICAL RECOMMENDATIONS</subject></subj-group></article-categories><title-group><article-title>Клиническая фармакология Серетида и его место в терапии бронхиальной астмы и хронических обструктивных заболеваний легких</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цой</surname><given-names>А. Н.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Архипов</surname><given-names>В. В.</given-names></name></name-alternatives><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беда</surname><given-names>М. В.</given-names></name></name-alternatives><bio xml:lang="ru"><p>медицинский отдел</p></bio><email xlink:type="simple">clinvest@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Московская медицинская академия им. И.М. Сеченова, г. Москва</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ГлаксоСмитКляйн, Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2002</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2008</year></pub-date><volume>0</volume><issue>1</issue><fpage>90</fpage><lpage>99</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Цой А.Н., Архипов В.В., Беда М.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Цой А.Н., Архипов В.В., Беда М.В.</copyright-holder><copyright-holder xml:lang="en">Цой А.Н., Архипов В.В., Беда М.В.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinvest.ru/jour/article/view/253">https://www.clinvest.ru/jour/article/view/253</self-uri><abstract/><kwd-group xml:lang="ru"><kwd>клиническая фармакология</kwd><kwd>Серетид</kwd><kwd>бронхиальная астма</kwd><kwd>хроническое обструктивное заболевание легких</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J., Pedersen S., Busse W.W. Efficacy and safety of inhaled corticosteroids Am J Respir Crit Care Med 1998; 157: s 51-s 53.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J., Pedersen S., Busse W.W. Efficacy and safety of inhaled corticosteroids Am J Respir Crit Care Med 1998; 157: s 51-s 53.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Guidelines for the Diagnosis and Management of asthma. Expert panel report, No.2. National institutes of health, Bethesda, MD. (NIP Publication No. 97-4051).</mixed-citation><mixed-citation xml:lang="en">Guidelines for the Diagnosis and Management of asthma. Expert panel report, No.2. National institutes of health, Bethesda, MD. (NIP Publication No. 97-4051).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Asthma in America web site: http://www.asthmainamerica.com/</mixed-citation><mixed-citation xml:lang="en">Asthma in America web site: http://www.asthmainamerica.com/</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Asthma Insights &amp; Reality in Europe web site: http://www.asthmaineurope.com/</mixed-citation><mixed-citation xml:lang="en">Asthma Insights &amp; Reality in Europe web site: http://www.asthmaineurope.com/</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Code of federal regulation &amp; ICH guidelines. Parexel / Barnett International Rose Tree Corporate Center. 2000.</mixed-citation><mixed-citation xml:lang="en">Code of federal regulation &amp; ICH guidelines. Parexel / Barnett International Rose Tree Corporate Center. 2000.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson H.S. Advair: Combination treatment with fluticasone propionate/salmeterol in the treatment of asthma. J Allergy Clin Immunol 2001; # 2; Vol. 107:397-416.</mixed-citation><mixed-citation xml:lang="en">Nelson H.S. Advair: Combination treatment with fluticasone propionate/salmeterol in the treatment of asthma. J Allergy Clin Immunol 2001; # 2; Vol. 107:397-416.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">TRISTAN COPD study. TRISTAN COPD Newsletter; 09.10.2001; p. 1-21.</mixed-citation><mixed-citation xml:lang="en">TRISTAN COPD study. TRISTAN COPD Newsletter; 09.10.2001; p. 1-21.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J. Effects of beta2-agonists and steroids on beta2-adrenoreceptor. Eur Respir Rev 1998; 8: 55; 210-215.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J. Effects of beta2-agonists and steroids on beta2-adrenoreceptor. Eur Respir Rev 1998; 8: 55; 210-215.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J., Chung K.F., Page C.P. Inflammatory Mediators of Asthma: An Update. PHARM. REV . 1998; Vol. 50, No. 4; 515-96.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J., Chung K.F., Page C.P. Inflammatory Mediators of Asthma: An Update. PHARM. REV . 1998; Vol. 50, No. 4; 515-96.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kia Soong Tan, McFarlane L.C., Lipworth B.J. Concomitant Administration of Low-Dose Prednisolone Protects Against In Vivo - Adrenoceptor Subsensitivity Induced by Regular Formoterol. Chest 1998; Vol. 113: # 1; 34-41.</mixed-citation><mixed-citation xml:lang="en">Kia Soong Tan, McFarlane L.C., Lipworth B.J. Concomitant Administration of Low-Dose Prednisolone Protects Against In Vivo - Adrenoceptor Subsensitivity Induced by Regular Formoterol. Chest 1998; Vol. 113: # 1; 34-41.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J. Effects of beta2-agonists on inflammatory cells. Journal of Allergy and Clinical Immunology. 1999; Vol. 104: # 2: 10-17.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J. Effects of beta2-agonists on inflammatory cells. Journal of Allergy and Clinical Immunology. 1999; Vol. 104: # 2: 10-17.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Imran Aziz, Hall I.P, McFarlane L.C. et al. ^-Adrenoceptor regulation and bronchodilator sensitivity after regular treatment with formoterol in subjects with stable asthma. Journal of Allergy and Clinical Immunology. 1998; Vol. 101: # 3: 337-341.</mixed-citation><mixed-citation xml:lang="en">Imran Aziz, Hall I.P, McFarlane L.C. et al. ^-Adrenoceptor regulation and bronchodilator sensitivity after regular treatment with formoterol in subjects with stable asthma. Journal of Allergy and Clinical Immunology. 1998; Vol. 101: # 3: 337-341.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Бронхиальная астма, глобальная стратегия. Основные направления лечения профилактики астмы: Всемирная организация здравоохранения, Национальный институт сердце, легкие и кровь. Март 1993. Пульмонология, 1996; Приложение 1. - 165 c.</mixed-citation><mixed-citation xml:lang="en">Бронхиальная астма, глобальная стратегия. Основные направления лечения профилактики астмы: Всемирная организация здравоохранения, Национальный институт сердце, легкие и кровь. Март 1993. Пульмонология, 1996; Приложение 1. - 165 c.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Woolcock A., Lundback B, Ringdal N, Jacques L.A. Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. Am J Respir Crit Care Med 1996;.153:1481-8.</mixed-citation><mixed-citation xml:lang="en">Woolcock A., Lundback B, Ringdal N, Jacques L.A. Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. Am J Respir Crit Care Med 1996;.153:1481-8.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">British Guidelines on Asthma Management. 1995 review and position statement. Thorax 1997;52(suppl 1):.1-21.</mixed-citation><mixed-citation xml:lang="en">British Guidelines on Asthma Management. 1995 review and position statement. Thorax 1997;52(suppl 1):.1-21.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Carndian asthma consensus report, 1999. CMAJ 1999; 161 [11 Suppl].</mixed-citation><mixed-citation xml:lang="en">Carndian asthma consensus report, 1999. CMAJ 1999; 161 [11 Suppl].</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Shrewsbury S, Pyke S, Britton M. Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (MIASMA). BMJ, 20 MAY 2000: Vol 320; 1368-1379.</mixed-citation><mixed-citation xml:lang="en">Shrewsbury S, Pyke S, Britton M. Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (MIASMA). BMJ, 20 MAY 2000: Vol 320; 1368-1379.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Nials A.T, Ball D.I., Butchers P.R. et al. Formoterol on airway smooth muscle and human lung mast cells: a comparison with salbutamol and salmeterol. Eur J Pharmacol 1994;251:127-35.</mixed-citation><mixed-citation xml:lang="en">Nials A.T, Ball D.I., Butchers P.R. et al. Formoterol on airway smooth muscle and human lung mast cells: a comparison with salbutamol and salmeterol. Eur J Pharmacol 1994;251:127-35.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Chong L.K., Cooper E, Vardey C.J., PeachellP.T. Salmeterol inhibition of mediator release from human lung mast cells by beta-adrenoceptor-dependent and independent mechanisms. Br J Pharmacol 1998;123:1009-15.</mixed-citation><mixed-citation xml:lang="en">Chong L.K., Cooper E, Vardey C.J., PeachellP.T. Salmeterol inhibition of mediator release from human lung mast cells by beta-adrenoceptor-dependent and independent mechanisms. Br J Pharmacol 1998;123:1009-15.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Proud D., Reynolds C.J., Lichtenstein L.M., Kagey-Sobotka A., Togias A. Intranasal salmeterol inhibits allergen-induced vascular permeability but not mast cell activation or cellular infiltration. Clin Exp Allergy 1998;28:868-75.</mixed-citation><mixed-citation xml:lang="en">Proud D., Reynolds C.J., Lichtenstein L.M., Kagey-Sobotka A., Togias A. Intranasal salmeterol inhibits allergen-induced vascular permeability but not mast cell activation or cellular infiltration. Clin Exp Allergy 1998;28:868-75.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Bissonnette E.Y., Befus D. Anti-inflammatory effect of beta2-agonists: inhibition of TNF-a release from human mast cells. J Allergy Clin Immunol 1997;100:825-31.</mixed-citation><mixed-citation xml:lang="en">Bissonnette E.Y., Befus D. Anti-inflammatory effect of beta2-agonists: inhibition of TNF-a release from human mast cells. J Allergy Clin Immunol 1997;100:825-31.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Butchers P.R., Vardey C.J., Johnson M. Salmeterol: a potent and long-acting inhibitor of inflammatory mediator release from human lung. Br J Pharmacol 1991;104:672-6.</mixed-citation><mixed-citation xml:lang="en">Butchers P.R., Vardey C.J., Johnson M. Salmeterol: a potent and long-acting inhibitor of inflammatory mediator release from human lung. Br J Pharmacol 1991;104:672-6.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Dowling R.B., Rayner C.F.J., Rutman A., Jackson A.D., Kanthakumar K., Dewar A. et al. Effect of salmeterol on Pseudomonas aeruginosa infection of respiratory mucosa. Am J Respir Crit Care Med 1997;155:327-36.</mixed-citation><mixed-citation xml:lang="en">Dowling R.B., Rayner C.F.J., Rutman A., Jackson A.D., Kanthakumar K., Dewar A. et al. Effect of salmeterol on Pseudomonas aeruginosa infection of respiratory mucosa. Am J Respir Crit Care Med 1997;155:327-36.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Dowling R.B., Johnson M, Cole P.J., Wilson R. Effect of salmeterol on Haemophilus influenzae infection of respiratory mucosa in vitro. Eur Respir J 1998;11:86-90.</mixed-citation><mixed-citation xml:lang="en">Dowling R.B., Johnson M, Cole P.J., Wilson R. Effect of salmeterol on Haemophilus influenzae infection of respiratory mucosa in vitro. Eur Respir J 1998;11:86-90.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Baraniuk J., Ali M., Brody D, Maniscalco J., Gaumond E, Fitzgerald T. et al. Glucocorticoids induce beta2 -adrenergic receptor function in human nasal mucosa. Am J Respir Crit Care Med 1997;155:704-10.</mixed-citation><mixed-citation xml:lang="en">Baraniuk J., Ali M., Brody D, Maniscalco J., Gaumond E, Fitzgerald T. et al. Glucocorticoids induce beta2 -adrenergic receptor function in human nasal mucosa. Am J Respir Crit Care Med 1997;155:704-10.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Eickelberg O., Roth M., Lorx R., Bruce V., Rudiger J., Johnson M. et al. Ligand-independent activation of glucocorticoid receptor by beta2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells. J Biol Chem 1999;274:1005-10.</mixed-citation><mixed-citation xml:lang="en">Eickelberg O., Roth M., Lorx R., Bruce V., Rudiger J., Johnson M. et al. Ligand-independent activation of glucocorticoid receptor by beta2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells. J Biol Chem 1999;274:1005-10.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Pang L., Knox A.J. Synergistic inhibition by ^-adrenoceptor agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells. Am J Respir Cell Mol Biol 2000;23:79-85.</mixed-citation><mixed-citation xml:lang="en">Pang L., Knox A.J. Synergistic inhibition by ^-adrenoceptor agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells. Am J Respir Cell Mol Biol 2000;23:79-85.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Pang L.H., Knox A.J. Inhibition by ^-adrenoceptor agonists and dexa-methasone on TNFalpha stimulated eotaxin release from human airway smooth muscle cells. Respir Med 1999;54(Suppl 3):A6.</mixed-citation><mixed-citation xml:lang="en">Pang L.H., Knox A.J. Inhibition by ^-adrenoceptor agonists and dexa-methasone on TNFalpha stimulated eotaxin release from human airway smooth muscle cells. Respir Med 1999;54(Suppl 3):A6.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Mak J.C.W., Nishikawa M., Shirasaki H., Miyayasu K., Barnes P.J. Protective effects of a glucocorticoid on downregulation of pulmonary beta2-adrenergic receptors in vivo. J Clin Invest 1995;96:99-106.</mixed-citation><mixed-citation xml:lang="en">Mak J.C.W., Nishikawa M., Shirasaki H., Miyayasu K., Barnes P.J. Protective effects of a glucocorticoid on downregulation of pulmonary beta2-adrenergic receptors in vivo. J Clin Invest 1995;96:99-106.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Mak J.C.W., Nishikawa M., Barnes P.J. Glucocorticosteroids increase beta-adrenergic receptor transcription in human lung. Am J Physiol 1995;268:L41-6.</mixed-citation><mixed-citation xml:lang="en">Mak J.C.W., Nishikawa M., Barnes P.J. Glucocorticosteroids increase beta-adrenergic receptor transcription in human lung. Am J Physiol 1995;268:L41-6.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Anenden V., Egemba G., Kessel B., Johnson M., Costello J. Salmeterol facilitation of fluticasone-induced apoptosis in eosinophils of asthmatics pre- and post-antigen challenge [abstract]. Eur Respir J 1998;12(Suppl 28):157 s.</mixed-citation><mixed-citation xml:lang="en">Anenden V., Egemba G., Kessel B., Johnson M., Costello J. Salmeterol facilitation of fluticasone-induced apoptosis in eosinophils of asthmatics pre- and post-antigen challenge [abstract]. Eur Respir J 1998;12(Suppl 28):157 s.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Mosby's Drug Consult. Mosby's GenRx®, 2002, 12th ed. Версия для Internet. Web site: http://www.mdconsult.com/</mixed-citation><mixed-citation xml:lang="en">Mosby's Drug Consult. Mosby's GenRx®, 2002, 12th ed. Версия для Internet. Web site: http://www.mdconsult.com/</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Pulmonary-Allergy Drugs Advisory Committee. Food and Drug Administration. 1995. Questions for the PADAC Meeting, September 25, 1995. U.S. Government Printing Office, Washington, DC.</mixed-citation><mixed-citation xml:lang="en">Pulmonary-Allergy Drugs Advisory Committee. Food and Drug Administration. 1995. Questions for the PADAC Meeting, September 25, 1995. U.S. Government Printing Office, Washington, DC.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Kavuru M., Melamed J., Gross G., LaForce C., House K., Prillaman B. et al. Salmeterol and fluticasone propionate combined in a new powder inhalation device for the treatment of asthma: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 2000;105:1108-16.</mixed-citation><mixed-citation xml:lang="en">Kavuru M., Melamed J., Gross G., LaForce C., House K., Prillaman B. et al. Salmeterol and fluticasone propionate combined in a new powder inhalation device for the treatment of asthma: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 2000;105:1108-16.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Shapiro G., Lumry W., Wolfe J., Given J., White M.V., Woodring A. et al. Combined salmeterol 50 mcg and fluticasone propionate 250 mcg in the Diskus device for the treatment of asthma. Am J Respir Crit Care Med 2000;161:S27-34.</mixed-citation><mixed-citation xml:lang="en">Shapiro G., Lumry W., Wolfe J., Given J., White M.V., Woodring A. et al. Combined salmeterol 50 mcg and fluticasone propionate 250 mcg in the Diskus device for the treatment of asthma. Am J Respir Crit Care Med 2000;161:S27-34.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Aubier M., Pieters W.R., Schlosser N.J., Steinmetz K-O. Salmeterol/fluticasone propionate (50/500 mcg) in combination in a Diskus® inhaler (Seretide®) is effective and safe in the treatment of steroid-dependent asthma. Respir Med 1999;93:876-84.</mixed-citation><mixed-citation xml:lang="en">Aubier M., Pieters W.R., Schlosser N.J., Steinmetz K-O. Salmeterol/fluticasone propionate (50/500 mcg) in combination in a Diskus® inhaler (Seretide®) is effective and safe in the treatment of steroid-dependent asthma. Respir Med 1999;93:876-84.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson H.S., Busse W.W., Kerwin E., Church N., Emmett A., Rickard K. et al. Fluticasone propionate/salmeterol combination provides more effective asthma control than low-dose inhaled corticosteroid plus montelukast. J Allergy Clin Immunol 2000;106:1088-95.</mixed-citation><mixed-citation xml:lang="en">Nelson H.S., Busse W.W., Kerwin E., Church N., Emmett A., Rickard K. et al. Fluticasone propionate/salmeterol combination provides more effective asthma control than low-dose inhaled corticosteroid plus montelukast. J Allergy Clin Immunol 2000;106:1088-95.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Цой А.Н. Применение системы доказательной медицины в лечении бронхиальной астмы // Русский медицинский журнал, 2001, № 1 (том 9), с. 4-8.</mixed-citation><mixed-citation xml:lang="en">Цой А.Н. Применение системы доказательной медицины в лечении бронхиальной астмы // Русский медицинский журнал, 2001, № 1 (том 9), с. 4-8.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Finkelstein F.N. Risks of salmeterol [letter]. N Engl J Med, 1994; p. 331-1314.</mixed-citation><mixed-citation xml:lang="en">Finkelstein F.N. Risks of salmeterol [letter]. N Engl J Med, 1994; p. 331-1314.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Greening A.P., Wind P.W., Northfield M., Shaw G. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Lancet, 1994; #344; p.219-224.</mixed-citation><mixed-citation xml:lang="en">Greening A.P., Wind P.W., Northfield M., Shaw G. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Lancet, 1994; #344; p.219-224.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Grove A., Lipworth B.J. Bronchodilator subsensitivity to salbutamol after twice daily salmeterol in asthmatic patients. Lancet, 1995; #346; p. 201-6.</mixed-citation><mixed-citation xml:lang="en">Grove A., Lipworth B.J. Bronchodilator subsensitivity to salbutamol after twice daily salmeterol in asthmatic patients. Lancet, 1995; #346; p. 201-6.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Wilkinson J.R.W., Roberts J.A., BraddingP., Holgate S.T., Howarth P.H. Paradoxical bronchoconstriction in asthmatic patients after salmeterol by metered dose inhaler. BMJ, 1992; #305; p. 931-932.</mixed-citation><mixed-citation xml:lang="en">Wilkinson J.R.W., Roberts J.A., BraddingP., Holgate S.T., Howarth P.H. Paradoxical bronchoconstriction in asthmatic patients after salmeterol by metered dose inhaler. BMJ, 1992; #305; p. 931-932.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Чучалин А.Г. Бронхиальная астма. М., 1997.</mixed-citation><mixed-citation xml:lang="en">Чучалин А.Г. Бронхиальная астма. М., 1997.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">British National Formulary. British Medical Association and Royal Pharmaceutical Society of Great Britan. # 38.</mixed-citation><mixed-citation xml:lang="en">British National Formulary. British Medical Association and Royal Pharmaceutical Society of Great Britan. # 38.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Postma D.S., Kerstjens H.A.M. Are Inhaled Glucocorticosteroids Effective in Chronic Obstructive Pulmonary Disease? Am J Respir Crit Care Med 1999;160: S66—S71.</mixed-citation><mixed-citation xml:lang="en">Postma D.S., Kerstjens H.A.M. Are Inhaled Glucocorticosteroids Effective in Chronic Obstructive Pulmonary Disease? Am J Respir Crit Care Med 1999;160: S66—S71.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Global Initiative for Chronic Obstructive Lung Disease. National Heart, Lung, and Blood Institute, NIH and World Health Organization. Executive summary. 2000.</mixed-citation><mixed-citation xml:lang="en">Global Initiative for Chronic Obstructive Lung Disease. National Heart, Lung, and Blood Institute, NIH and World Health Organization. Executive summary. 2000.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson M. в-Adrenoceptor. Am. J. Respir. Crit. Care Med., Volume 158, Number 5, November 1998, S.146-153.</mixed-citation><mixed-citation xml:lang="en">Johnson M. в-Adrenoceptor. Am. J. Respir. Crit. Care Med., Volume 158, Number 5, November 1998, S.146-153.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Newnham D.M., Grove A., McDevitt D.G., Lipworth B.J. Subsensitivity of bronchodilator and systemic beta2-adrenoceptor responses after regular twice daily treatment with eformoterol dry powder in asthmatic patients. Thorax 1995;50:497-504.</mixed-citation><mixed-citation xml:lang="en">Newnham D.M., Grove A., McDevitt D.G., Lipworth B.J. Subsensitivity of bronchodilator and systemic beta2-adrenoceptor responses after regular twice daily treatment with eformoterol dry powder in asthmatic patients. Thorax 1995;50:497-504.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J, Woolcock A.J. Difficult asthma. Eur Respir J 1998; 12: 1209-1218.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J, Woolcock A.J. Difficult asthma. Eur Respir J 1998; 12: 1209-1218.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
