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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinvest</journal-id><journal-title-group><journal-title xml:lang="ru">Качественная клиническая практика</journal-title><trans-title-group xml:lang="en"><trans-title>Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2588-0519</issn><issn pub-type="epub">2618-8473</issn><publisher><publisher-name>ООО «Издательство ОКИ</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">clinvest-116</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФАРМАКОЭКОНОМИКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACOECONOMICS</subject></subj-group></article-categories><title-group><article-title>Клинико-экономические аспекты терапии болезни Альцгеймера в России</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белоусов</surname><given-names>Ю. Б.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зырянов</surname><given-names>С. К.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белоусов</surname><given-names>Д. Ю.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бекетов</surname><given-names>А. С.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова», Москва</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ООО "Центр фармакоэкономических исследований", г. Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>05</day><month>06</month><year>2018</year></pub-date><volume>0</volume><issue>1</issue><fpage>3</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Белоусов Ю.Б., Зырянов С.К., Белоусов Д.Ю., Бекетов А.С., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Белоусов Ю.Б., Зырянов С.К., Белоусов Д.Ю., Бекетов А.С.</copyright-holder><copyright-holder xml:lang="en">Белоусов Ю.Б., Зырянов С.К., Белоусов Д.Ю., Бекетов А.С.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.clinvest.ru/jour/article/view/116">https://www.clinvest.ru/jour/article/view/116</self-uri><abstract><p>Экселон ТТС обладает необходимыми клинико-экономическими характеристиками для включения в государственные программы лечения деменции. Он превосходит по показателю минимизации затрат Реминил (галантамин) и Акатинол (мемантина гидрохлорид), включенные в программу государственного возмещения. Суммируя экономичность с определенными клиническими позитивными преимуществами Экселона ТТС, можно сделать вывод о необходимости предпочтения Экселона ТТС для фармакотерапии болезни Альцгеймера.</p></abstract><kwd-group xml:lang="ru"><kwd>фармакоэкономика</kwd><kwd>Экселон ТТС</kwd><kwd>болезнь Альцгеймера</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">.Бачурин С.О. Медико-химические подходы к направленному поиску препаратов для лечения и предупреждения болезни Альцгеймера . // Вопросы медицинской химии, 2001, №2 . Эл . версия доступна на www .medi .ru/pbmc/8810201 .htm</mixed-citation><mixed-citation xml:lang="en">.Бачурин С.О. Медико-химические подходы к направленному поиску препаратов для лечения и предупреждения болезни Альцгеймера . // Вопросы медицинской химии, 2001, №2 . Эл . версия доступна на www .medi .ru/pbmc/8810201 .htm</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">.Дамулин И.В. Болезнь Альцгеймера: некоторые клинические и терапевтические аспекты . Consilium Medicum 2004; T6 (№8):</mixed-citation><mixed-citation xml:lang="en">.Дамулин И.В. Болезнь Альцгеймера: некоторые клинические и терапевтические аспекты . Consilium Medicum 2004; T6 (№8):</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">.Елагин Е.И. Переносимость и безопасность ингибиторов холинэстеразы в лечении деменции . Consilium Medicum 2005; T7 (№2)</mixed-citation><mixed-citation xml:lang="en">.Елагин Е.И. Переносимость и безопасность ингибиторов холинэстеразы в лечении деменции . Consilium Medicum 2005; T7 (№2)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">.Захаров В.В., Яхно Н.Н. Нарушения памяти . М .: Гэотар-Мед, 2003 .</mixed-citation><mixed-citation xml:lang="en">.Захаров В.В., Яхно Н.Н. Нарушения памяти . М .: Гэотар-Мед, 2003 .</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">.Population Division of the Department of Economic and Social Affairs of the United Nations Secretariat, World Population Prospects: The 2008 Revision, http:// esa .un .org/unpp,, Sunday, May 03, 2009 .</mixed-citation><mixed-citation xml:lang="en">.Population Division of the Department of Economic and Social Affairs of the United Nations Secretariat, World Population Prospects: The 2008 Revision, http:// esa .un .org/unpp,, Sunday, May 03, 2009 .</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">.Здравоохранение в России: Стат .сб ./ Госкомстат России . М ., 2001 . — 356 с</mixed-citation><mixed-citation xml:lang="en">.Здравоохранение в России: Стат .сб ./ Госкомстат России . М ., 2001 . — 356 с</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">.Калын Я.Б. Клиника инициальных проявлений и особенности последующего течения сенильной деменции//Дис . . . .канд . мед . наук . М ., 1990; 220</mixed-citation><mixed-citation xml:lang="en">.Калын Я.Б. Клиника инициальных проявлений и особенности последующего течения сенильной деменции//Дис . . . .канд . мед . наук . М ., 1990; 220</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">.Калын Я.Б., Брацун А.Л. Деменции альцгеймеровского типа: эпидемиология и факторы риска // Психиатрия и психофармакотерапия 2001; 2</mixed-citation><mixed-citation xml:lang="en">.Калын Я.Б., Брацун А.Л. Деменции альцгеймеровского типа: эпидемиология и факторы риска // Психиатрия и психофармакотерапия 2001; 2</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">.Коршунов А.М., Преображенская И.С. Неврол . журн . 1998; 3 (1): 40–6</mixed-citation><mixed-citation xml:lang="en">.Коршунов А.М., Преображенская И.С. Неврол . журн . 1998; 3 (1): 40–6</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">.Прейскурант на оказание медицинских услуг ММА им . Сеченова, г . Москвы, 2009 г .</mixed-citation><mixed-citation xml:lang="en">.Прейскурант на оказание медицинских услуг ММА им . Сеченова, г . Москвы, 2009 г .</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">.Российский статистический ежегодник, 2004 .</mixed-citation><mixed-citation xml:lang="en">.Российский статистический ежегодник, 2004 .</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">.Российский статистический ежегодник . 2006: Стат .сб/Росстат . — М ., 2006 . — 806 с .</mixed-citation><mixed-citation xml:lang="en">.Российский статистический ежегодник . 2006: Стат .сб/Росстат . — М ., 2006 . — 806 с .</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">.Численность населения Российской Федерации по полу и возрасту на 1 января 2006 года . Статистический бюллетень . Росстат . — М ., 2006</mixed-citation><mixed-citation xml:lang="en">.Численность населения Российской Федерации по полу и возрасту на 1 января 2006 года . Статистический бюллетень . Росстат . — М ., 2006</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">.Численность населения Российской Федерации по полу и возрасту на 1 января 2005 года . Статистический бюллетень . Росстат . — М ., 2005</mixed-citation><mixed-citation xml:lang="en">.Численность населения Российской Федерации по полу и возрасту на 1 января 2005 года . Статистический бюллетень . Росстат . — М ., 2005</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">.Численность населения Российской Федерации по полу и возрасту на 1 января 2004 года . Статистический бюллетень . Росстат . — М ., 2004</mixed-citation><mixed-citation xml:lang="en">.Численность населения Российской Федерации по полу и возрасту на 1 января 2004 года . Статистический бюллетень . Росстат . — М ., 2004</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">.Яхно Н.Н., Захаров В.В. Невролог . журн . 1997; 4: 4–9</mixed-citation><mixed-citation xml:lang="en">.Яхно Н.Н., Захаров В.В. Невролог . журн . 1997; 4: 4–9</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">.Adler G., Brassen S. Short-term rivastigmine treatment reduces EEG slow-wave power in Alzheimer patients . Neuropsychobiology . 2001; 43 (4): 273-276</mixed-citation><mixed-citation xml:lang="en">.Adler G., Brassen S. Short-term rivastigmine treatment reduces EEG slow-wave power in Alzheimer patients . Neuropsychobiology . 2001; 43 (4): 273-276</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">.Aguglia E., Onor M.L., Saina M., Maso E. An open-label, comparative study of rivastigmine, donepezil and galantamine in a real-world setting // Curr Med Res Opin . 2004;20 (11): 1747-1752</mixed-citation><mixed-citation xml:lang="en">.Aguglia E., Onor M.L., Saina M., Maso E. An open-label, comparative study of rivastigmine, donepezil and galantamine in a real-world setting // Curr Med Res Opin . 2004;20 (11): 1747-1752</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">.Amici S., Lanari A., Romani R., Antognelli C., Gallai V., et al. Cerebrospinal fluid acetylcholinesterase activity after long-term treatment with donepezil and rivastigmina . Mechanisms of Ageing and Development . 2001; 122 (16): 2057-2062</mixed-citation><mixed-citation xml:lang="en">.Amici S., Lanari A., Romani R., Antognelli C., Gallai V., et al. Cerebrospinal fluid acetylcholinesterase activity after long-term treatment with donepezil and rivastigmina . Mechanisms of Ageing and Development . 2001; 122 (16): 2057-2062</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">.Arai M. Parkinsonism onset in a patient concurrently using tiapride and donepezil . Internal Medicine . 2000; 39 (10): 863</mixed-citation><mixed-citation xml:lang="en">.Arai M. Parkinsonism onset in a patient concurrently using tiapride and donepezil . Internal Medicine . 2000; 39 (10): 863</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">.Arendt T., Bruckner M.K., Lange M., Bigl V. Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer’s disease resemble embryonic development—a study of molecular forms . Neurochemistry International . 1992; 21: 381 –396</mixed-citation><mixed-citation xml:lang="en">.Arendt T., Bruckner M.K., Lange M., Bigl V. Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer’s disease resemble embryonic development—a study of molecular forms . Neurochemistry International . 1992; 21: 381 –396</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">.Areosa S.A., Sherriff F. Memantine for dementia . Cochrane Database of Systematic Reviews 2003; (1): CD003154 . Review . Update in: Cochrane Database Syst Rev . 2003;(3):CD003154</mixed-citation><mixed-citation xml:lang="en">.Areosa S.A., Sherriff F. Memantine for dementia . Cochrane Database of Systematic Reviews 2003; (1): CD003154 . Review . Update in: Cochrane Database Syst Rev . 2003;(3):CD003154</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">.Ballard C.G. Advances in the treatment of Alzheimer’s disease: benefits of dual cholinesterase inhibition . European Neurology . 2002; 47: 64 –70</mixed-citation><mixed-citation xml:lang="en">.Ballard C.G. Advances in the treatment of Alzheimer’s disease: benefits of dual cholinesterase inhibition . European Neurology . 2002; 47: 64 –70</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">.Barner E.L., Gray S.L. Donepezil use in Alzheimer disease . Annals of Pharmacotherapy . 1998; 32 (1): 70-77 .</mixed-citation><mixed-citation xml:lang="en">.Barner E.L., Gray S.L. Donepezil use in Alzheimer disease . Annals of Pharmacotherapy . 1998; 32 (1): 70-77 .</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">.Birks J., Flicker L. Selegiline for Alzheimer’s disease . Cochrane Database of Systematic Reviews . 2003; (1): CD000442</mixed-citation><mixed-citation xml:lang="en">.Birks J., Flicker L. Selegiline for Alzheimer’s disease . Cochrane Database of Systematic Reviews . 2003; (1): CD000442</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">.Birks J., Grimley Evans J., Iakovidou V., Tsolaki M. Rivastigmine for Alzheimer’s disease . Cochrane Database Systematic Review . 2000; (4): CD001191</mixed-citation><mixed-citation xml:lang="en">.Birks J., Grimley Evans J., Iakovidou V., Tsolaki M. Rivastigmine for Alzheimer’s disease . Cochrane Database Systematic Review . 2000; (4): CD001191</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">.Birks J.S., Harvey R. Donepezil for dementia due to Alzheimer’s disease . Cochrane Database of Systematic Reviews 2003; (3): CD001190</mixed-citation><mixed-citation xml:lang="en">.Birks J.S., Harvey R. Donepezil for dementia due to Alzheimer’s disease . Cochrane Database of Systematic Reviews 2003; (3): CD001190</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">.Bouman W.P., Pinner G. Violent behavior-associated with donepezil . American Journal of Psychiatry . 1998; 155 (11): 1626-1627 .</mixed-citation><mixed-citation xml:lang="en">.Bouman W.P., Pinner G. Violent behavior-associated with donepezil . American Journal of Psychiatry . 1998; 155 (11): 1626-1627 .</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">.Bourke D., Druckenbrod R.W. Possible association between donepezil and worsening Parkinson’s disease . Annals of Pharmacotherapy . 1998; 32 (5): 610-611</mixed-citation><mixed-citation xml:lang="en">.Bourke D., Druckenbrod R.W. Possible association between donepezil and worsening Parkinson’s disease . Annals of Pharmacotherapy . 1998; 32 (5): 610-611</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">.Bullock R., Cameron A. Rivastigmine for the treatment of dementia and visual hallucinations associated with Parkinson’s disease: a case series . Current Medical Research and Opinion . 2002; 18 (5): 258-264</mixed-citation><mixed-citation xml:lang="en">.Bullock R., Cameron A. Rivastigmine for the treatment of dementia and visual hallucinations associated with Parkinson’s disease: a case series . Current Medical Research and Opinion . 2002; 18 (5): 258-264</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">.Burns A., Rossor M., Hecker J., Gauthier S., Petit H., et al. The effects of donepezil in Alzheimer’s disease — results from a multinational trial . Dementia and Geriatric Cognitive Disorders . 1999; 10 (3): 237-244</mixed-citation><mixed-citation xml:lang="en">.Burns A., Rossor M., Hecker J., Gauthier S., Petit H., et al. The effects of donepezil in Alzheimer’s disease — results from a multinational trial . Dementia and Geriatric Cognitive Disorders . 1999; 10 (3): 237-244</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">.Calvo-Romero J.M., Ramos-Salado J.L. Symptomatic sinus bradycardia associated with donepezil . Revista de Neurologia . 1999; 28 (11): 1070-1072</mixed-citation><mixed-citation xml:lang="en">.Calvo-Romero J.M., Ramos-Salado J.L. Symptomatic sinus bradycardia associated with donepezil . Revista de Neurologia . 1999; 28 (11): 1070-1072</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">.Canadian Adverse Drug Reaction Monitoring Program . Donepezil: suspected adverse reactions . Canadian Medical Association Journal 1998; 159:81</mixed-citation><mixed-citation xml:lang="en">.Canadian Adverse Drug Reaction Monitoring Program . Donepezil: suspected adverse reactions . Canadian Medical Association Journal 1998; 159:81</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">.Coelho F., Birks J. Physostigmine for Alzheimer’s disease // Cochrane Database of Systematic Reviews 2001; (2): CD001499 .</mixed-citation><mixed-citation xml:lang="en">.Coelho F., Birks J. Physostigmine for Alzheimer’s disease // Cochrane Database of Systematic Reviews 2001; (2): CD001499 .</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">.Cummings J.L., Kaufer D. Neuropsychiatric aspects of Alzheimer‘s disease: the cholinergic hypothesis revisited . Neurology . 1996; 47 (4): 876-883 .</mixed-citation><mixed-citation xml:lang="en">.Cummings J.L., Kaufer D. Neuropsychiatric aspects of Alzheimer‘s disease: the cholinergic hypothesis revisited . Neurology . 1996; 47 (4): 876-883 .</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">.Cummings JL. In: Alzheimer’s Disease . Treatment and Long-Term Management . Ed . by J .L .Cummings, B .L .Miller . New York, Basel: Marcel Dekker, Inc ., 1990; P . 3–19 .</mixed-citation><mixed-citation xml:lang="en">.Cummings JL. In: Alzheimer’s Disease . Treatment and Long-Term Management . Ed . by J .L .Cummings, B .L .Miller . New York, Basel: Marcel Dekker, Inc ., 1990; P . 3–19 .</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">.Cutler N.R., Polinsky R.J., Sramek J.J., Enz A., Jhee S.S., et al. Dose-dependent CSF acetylcholinesterase inhibition by SDZ ENA 713 in Alzheimer’s disease . Acta Neurologica Scandinavica . . 1998; 97 (4): 244-250</mixed-citation><mixed-citation xml:lang="en">.Cutler N.R., Polinsky R.J., Sramek J.J., Enz A., Jhee S.S., et al. Dose-dependent CSF acetylcholinesterase inhibition by SDZ ENA 713 in Alzheimer’s disease . Acta Neurologica Scandinavica . . 1998; 97 (4): 244-250</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">.Davidsson P., Blennow K., Andreasen N., Eriksson B., Minthon L., et al. Differential increase in cerebrospinal fluid–acetylcholinesterase after treatment with acetyl-cholinesterase inhibitors in patients with Alzheimer’s disease . Neuroscience Letter .2001; 300: 157 –160</mixed-citation><mixed-citation xml:lang="en">.Davidsson P., Blennow K., Andreasen N., Eriksson B., Minthon L., et al. Differential increase in cerebrospinal fluid–acetylcholinesterase after treatment with acetyl-cholinesterase inhibitors in patients with Alzheimer’s disease . Neuroscience Letter .2001; 300: 157 –160</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">.Davies P., Maloney A.J. Selective loss of central cholinergic neurons in Alzheimer’s disease . Lancet .1976; 2: 1403</mixed-citation><mixed-citation xml:lang="en">.Davies P., Maloney A.J. Selective loss of central cholinergic neurons in Alzheimer’s disease . Lancet .1976; 2: 1403</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">.Dunn N.R., Pearce G.L., Shakir S.A. Adverse effects associated with the use of donepezil in general practice in England . Journal of Psychopharmacology 2000; 14 (4): 406-408</mixed-citation><mixed-citation xml:lang="en">.Dunn N.R., Pearce G.L., Shakir S.A. Adverse effects associated with the use of donepezil in general practice in England . Journal of Psychopharmacology 2000; 14 (4): 406-408</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">.Enz A., Amstutz R., Boddeke H., Gmelin G., Malanowski J. Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer’s disease . Progress in Brain Research . 1993; 98: 431-438</mixed-citation><mixed-citation xml:lang="en">.Enz A., Amstutz R., Boddeke H., Gmelin G., Malanowski J. Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer’s disease . Progress in Brain Research . 1993; 98: 431-438</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">.Enz A., Boddeke H., Gray J., Spiegel R. Pharmacologic and clinicopharmacologic properties of SDZ ENA 713, a centrally selective acetylcholinesterase inhibitor . Annals of the N-Y Academy of Sciences . 1991; 640: 272-275</mixed-citation><mixed-citation xml:lang="en">.Enz A., Boddeke H., Gray J., Spiegel R. Pharmacologic and clinicopharmacologic properties of SDZ ENA 713, a centrally selective acetylcholinesterase inhibitor . Annals of the N-Y Academy of Sciences . 1991; 640: 272-275</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">.Erkinjuntti T., Kurz A., Gauthier S., Bullock R., Lilienfeld S., et al. Efficacy of galantamine in probable vascular dementia and Alzheimer’s disease combined with cerebrovascular disease: a randomised trial . Lancet . 2002; 359 (9314): 1283-1290</mixed-citation><mixed-citation xml:lang="en">.Erkinjuntti T., Kurz A., Gauthier S., Bullock R., Lilienfeld S., et al. Efficacy of galantamine in probable vascular dementia and Alzheimer’s disease combined with cerebrovascular disease: a randomised trial . Lancet . 2002; 359 (9314): 1283-1290</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">.Etemad B. Behavioral and cognitive benefits of rivastigmine in nursing home patients with Alzheimer’s Disease and related dementias: a 26-week follow-up . Internal Psychogeriatrics 2001; 13 (Suppl 2): 241</mixed-citation><mixed-citation xml:lang="en">.Etemad B. Behavioral and cognitive benefits of rivastigmine in nursing home patients with Alzheimer’s Disease and related dementias: a 26-week follow-up . Internal Psychogeriatrics 2001; 13 (Suppl 2): 241</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">.Evans D.A., Funkenstein H.H., Albert M.S., et al. Prevalence of Alzheimer’s Disease in a community population of older person Higher than previously reported // JAMA, 1989; 262: 2551-2556</mixed-citation><mixed-citation xml:lang="en">.Evans D.A., Funkenstein H.H., Albert M.S., et al. Prevalence of Alzheimer’s Disease in a community population of older person Higher than previously reported // JAMA, 1989; 262: 2551-2556</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">.Farlow M.R. Do cholinesterase inhibitors slow progression of Alzheimer’s disease? International Journal of Clinical Practice 2002; Suppl (127): 37-44</mixed-citation><mixed-citation xml:lang="en">.Farlow M.R. Do cholinesterase inhibitors slow progression of Alzheimer’s disease? International Journal of Clinical Practice 2002; Suppl (127): 37-44</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">.Fioravanti M., Flicker L. Efficacy of nicergoline in dementia and other age associated forms of cognitive impairment // Cochrane Database of Systematic Reviews . 2001; (4): CD003159</mixed-citation><mixed-citation xml:lang="en">.Fioravanti M., Flicker L. Efficacy of nicergoline in dementia and other age associated forms of cognitive impairment // Cochrane Database of Systematic Reviews . 2001; (4): CD003159</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">.Fioravanti M., Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly . Cochrane Database of Systematic Review . 2005 18; (2): CD000269</mixed-citation><mixed-citation xml:lang="en">.Fioravanti M., Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly . Cochrane Database of Systematic Review . 2005 18; (2): CD000269</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">.Flicker L., Grimley Evans J. Piracetam for dementia or cognitive impairment . Cochrane Database of Systemqtic Review . 2000; (2): CD001011 . Update in: Cochrane Database of Systemativ Review . 2001; (2): CD001011</mixed-citation><mixed-citation xml:lang="en">.Flicker L., Grimley Evans J. Piracetam for dementia or cognitive impairment . Cochrane Database of Systemqtic Review . 2000; (2): CD001011 . Update in: Cochrane Database of Systemativ Review . 2001; (2): CD001011</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">.Fraser M., Snyder E.H. Jr. The economic benefits of delaying progression in Alzheimer’s Disease using cholinesterase inhibitors . Clinical Geriatrics . 2000; 8 (2): 1-12</mixed-citation><mixed-citation xml:lang="en">.Fraser M., Snyder E.H. Jr. The economic benefits of delaying progression in Alzheimer’s Disease using cholinesterase inhibitors . Clinical Geriatrics . 2000; 8 (2): 1-12</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">.Giacobini E. Cholinesterase inhibitors: from the calabar bean to Alzheimer therapy . In: Giacobini E ., Ed . Cholonesterases and cholinesterase inhibitors . London: Martin Dunitz Ltd, 2000: 181-226</mixed-citation><mixed-citation xml:lang="en">.Giacobini E. Cholinesterase inhibitors: from the calabar bean to Alzheimer therapy . In: Giacobini E ., Ed . Cholonesterases and cholinesterase inhibitors . London: Martin Dunitz Ltd, 2000: 181-226</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">.Giladi N., Shabtai H., Gurevich T., Benbunan B., Anca M., Korczyn A.D. Rivastigmine (Exelon) for dementia in patients with Parkinson’s disease . Acta Neurologica Scandinavica . 2003; 108 (5): 368-373</mixed-citation><mixed-citation xml:lang="en">.Giladi N., Shabtai H., Gurevich T., Benbunan B., Anca M., Korczyn A.D. Rivastigmine (Exelon) for dementia in patients with Parkinson’s disease . Acta Neurologica Scandinavica . 2003; 108 (5): 368-373</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">.Glennie J., for the Canadian Coordinating Office for Health Technology Assessment (CCOHTA) . Review: Tacrine has limited efficacy for Alzheimer disease» . ACP J Club 1997;128:46 . Перевод представлен на http://www .mediasphera .aha .ru/mjmp/98/5/r5-98-5 .htm</mixed-citation><mixed-citation xml:lang="en">.Glennie J., for the Canadian Coordinating Office for Health Technology Assessment (CCOHTA) . Review: Tacrine has limited efficacy for Alzheimer disease» . ACP J Club 1997;128:46 . Перевод представлен на http://www .mediasphera .aha .ru/mjmp/98/5/r5-98-5 .htm</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">.Grace J., Daniel S., Stevens T., Shankar K.K., Walker Z., et al. Long-Term use of rivastigmine in patients with dementia with Lewy bodies: an open-label trial . International Psychogeriatrics . 2001; 13 (2): 199-205</mixed-citation><mixed-citation xml:lang="en">.Grace J., Daniel S., Stevens T., Shankar K.K., Walker Z., et al. Long-Term use of rivastigmine in patients with dementia with Lewy bodies: an open-label trial . International Psychogeriatrics . 2001; 13 (2): 199-205</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">.Greenberg S.M., Tennis M.K., Brown L.B., Gomez-Isla T., Hayden D.L., et al. Donepezil therapy in clinical practice: a randomized crossover study . Archives of Neurology . 2000; 57 (1): 94-99</mixed-citation><mixed-citation xml:lang="en">.Greenberg S.M., Tennis M.K., Brown L.B., Gomez-Isla T., Hayden D.L., et al. Donepezil therapy in clinical practice: a randomized crossover study . Archives of Neurology . 2000; 57 (1): 94-99</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">.Greig N.H., Utsuki T., Yu Q., Zhu X., Holloway H.W., et al. A new therapeutic target in Alzheimer’s disease treatment: attention to butyrylcholinesterase [review] . Current Medical Research and Opinion . 2001; 17: 159 –165</mixed-citation><mixed-citation xml:lang="en">.Greig N.H., Utsuki T., Yu Q., Zhu X., Holloway H.W., et al. A new therapeutic target in Alzheimer’s disease treatment: attention to butyrylcholinesterase [review] . Current Medical Research and Opinion . 2001; 17: 159 –165</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">.Grossberg G., Irwin P., Satlin A., Mesenbrink P., Spiegel R. Rivastigmine in Alzheimer disease: efficacy over two years . American Journal of Geriatric Psychiatry . 2004; 12 (4): 420-431 . Erratum in: American Journal of Geriatric Psychiatry . 2004; 12 (6): 679</mixed-citation><mixed-citation xml:lang="en">.Grossberg G., Irwin P., Satlin A., Mesenbrink P., Spiegel R. Rivastigmine in Alzheimer disease: efficacy over two years . American Journal of Geriatric Psychiatry . 2004; 12 (4): 420-431 . Erratum in: American Journal of Geriatric Psychiatry . 2004; 12 (6): 679</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">.Grossberg G., Irwin P., Spiegel R., et al. Rivastigmine in Alzheimer’s Disease: efficacy over 2 years compared with historical controls .Poster presented at the International Psychogeriatric Association, Nice, France, 9-14 September, 2001</mixed-citation><mixed-citation xml:lang="en">.Grossberg G., Irwin P., Spiegel R., et al. Rivastigmine in Alzheimer’s Disease: efficacy over 2 years compared with historical controls .Poster presented at the International Psychogeriatric Association, Nice, France, 9-14 September, 2001</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">.Guillozet A., Smiley J.F., Mash D.C., Mesulam M.M. Butyrylcholinesterase in the life cycle of amyloid plaques . Annals of Neurology .1997; 42: 909 –918</mixed-citation><mixed-citation xml:lang="en">.Guillozet A., Smiley J.F., Mash D.C., Mesulam M.M. Butyrylcholinesterase in the life cycle of amyloid plaques . Annals of Neurology .1997; 42: 909 –918</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">.Hashimoto M., Imamura T., Tanimukai S., Kazui H., Mori E. Urinary incontinence: an unrecognised adverse effect with donepezil . Lancet . 2000; 356 (9229): 568</mixed-citation><mixed-citation xml:lang="en">.Hashimoto M., Imamura T., Tanimukai S., Kazui H., Mori E. Urinary incontinence: an unrecognised adverse effect with donepezil . Lancet . 2000; 356 (9229): 568</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">.Inglis F. The tolerability and safety of cholinesterase inhibitors in the treatment of dementia . // International Journal of Clinical Pharmacology 2002; Suppl . 127: 45–63 .</mixed-citation><mixed-citation xml:lang="en">.Inglis F. The tolerability and safety of cholinesterase inhibitors in the treatment of dementia . // International Journal of Clinical Pharmacology 2002; Suppl . 127: 45–63 .</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">.Kanowski S., Herrmann W.M., Stephan K., et al. Proof of efficacy of the ginkgo biloba special extract Egb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia . Pharmacopsychiatry 1996; 29: 47-56</mixed-citation><mixed-citation xml:lang="en">.Kanowski S., Herrmann W.M., Stephan K., et al. Proof of efficacy of the ginkgo biloba special extract Egb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia . Pharmacopsychiatry 1996; 29: 47-56</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">.Kasa P., Papp H., Kasa P. Jr, Torok I. Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain . Neuroscience . 2000; 101 (1): 89-100</mixed-citation><mixed-citation xml:lang="en">.Kasa P., Papp H., Kasa P. Jr, Torok I. Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain . Neuroscience . 2000; 101 (1): 89-100</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">.Kennedy J.S., Polinsky R.J., Johnson B., Loosen P., Enz A., et al. Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans . Journal of Clinical Psychopharmacology . 1999; 19 (6): 513-521</mixed-citation><mixed-citation xml:lang="en">.Kennedy J.S., Polinsky R.J., Johnson B., Loosen P., Enz A., et al. Preferential cerebrospinal fluid acetylcholinesterase inhibition by rivastigmine in humans . Journal of Clinical Psychopharmacology . 1999; 19 (6): 513-521</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">.Kuhl D.E., Minoshima S., Frey K.A., Foster N.L., Kilbourn M.R., et al. Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex . Annals of Neurology . 2000; 48 (3): 391-395</mixed-citation><mixed-citation xml:lang="en">.Kuhl D.E., Minoshima S., Frey K.A., Foster N.L., Kilbourn M.R., et al. Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex . Annals of Neurology . 2000; 48 (3): 391-395</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">.Kumar V., Anand R., Messina J., Hartman R., Veach J. An efficacy and safety analysis of Exelon in Alzheimer’s disease patients with concurrent vascular risk factors . European Journal of Neurology . 2000; 7 (2): 159-169</mixed-citation><mixed-citation xml:lang="en">.Kumar V., Anand R., Messina J., Hartman R., Veach J. An efficacy and safety analysis of Exelon in Alzheimer’s disease patients with concurrent vascular risk factors . European Journal of Neurology . 2000; 7 (2): 159-169</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">.Lane R.M. Pharmacokinetic drug interaction potential of selective serotonin reuptake inhibitors . International Clinical Psychopharmacology . 1996; 11 ( Suppl 5): 31-61 . Review . Erratum in: International Clinical Psychopharmacology 1997; 12 (2): 126</mixed-citation><mixed-citation xml:lang="en">.Lane R.M. Pharmacokinetic drug interaction potential of selective serotonin reuptake inhibitors . International Clinical Psychopharmacology . 1996; 11 ( Suppl 5): 31-61 . Review . Erratum in: International Clinical Psychopharmacology 1997; 12 (2): 126</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">.Le Bars P.L., Kieser M., Itil K.Z. A 26 week analysis of a doubleblind, placebo-controlled trial of the Ginkgo biloba extract Egb 761 in dementia . Dementia Geriatric Cognitive Disorders 2000; 11: 230-237</mixed-citation><mixed-citation xml:lang="en">.Le Bars P.L., Kieser M., Itil K.Z. A 26 week analysis of a doubleblind, placebo-controlled trial of the Ginkgo biloba extract Egb 761 in dementia . Dementia Geriatric Cognitive Disorders 2000; 11: 230-237</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">.Lehmann D.J., Johnston C., Smith A.D. Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer’s disease // Hum Mol Genet . 1997; 6 (11): 1933-1936</mixed-citation><mixed-citation xml:lang="en">.Lehmann D.J., Johnston C., Smith A.D. Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer’s disease // Hum Mol Genet . 1997; 6 (11): 1933-1936</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">.Lehmann D.J., Nagy Z., Litchfield S., Borja M.C., Smith A.D. Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer’s disease . Human Genetics . 2000; 106 (4): 447-452</mixed-citation><mixed-citation xml:lang="en">.Lehmann D.J., Nagy Z., Litchfield S., Borja M.C., Smith A.D. Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer’s disease . Human Genetics . 2000; 106 (4): 447-452</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">.Li B., Stribley J.A., Ticu A., Xie W., Schopfer L.M., et al. Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse // Journal of Neurochemistry . 2000; 75 (3): 1320-1331</mixed-citation><mixed-citation xml:lang="en">.Li B., Stribley J.A., Ticu A., Xie W., Schopfer L.M., et al. Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse // Journal of Neurochemistry . 2000; 75 (3): 1320-1331</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">.Lovenstone S., Gauthier S. Management of Dementia . London: Martin Dunitz, 2001 .</mixed-citation><mixed-citation xml:lang="en">.Lovenstone S., Gauthier S. Management of Dementia . London: Martin Dunitz, 2001 .</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">.Magnuson T.M., Keller B.K., Burke W.J. Extrapyramidal side effects in a patient treated with risperidone plus donepezil . American Journal of Psychiatry . 1998; 155 (10): 1458-1459 .</mixed-citation><mixed-citation xml:lang="en">.Magnuson T.M., Keller B.K., Burke W.J. Extrapyramidal side effects in a patient treated with risperidone plus donepezil . American Journal of Psychiatry . 1998; 155 (10): 1458-1459 .</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">.Malouf R., Birks J. Donepezil for vascular cognitive impairment // Cochrane Database of Systematic Reviews 2004; (1): CD004395 .</mixed-citation><mixed-citation xml:lang="en">.Malouf R., Birks J. Donepezil for vascular cognitive impairment // Cochrane Database of Systematic Reviews 2004; (1): CD004395 .</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">.Maurer I., Zierz S., Moller H.J., Jerusalem F. Cytochrome c oxidase in Alzheimer’s disease // Neurology . 1995; 45 (7): 1423 .</mixed-citation><mixed-citation xml:lang="en">.Maurer I., Zierz S., Moller H.J., Jerusalem F. Cytochrome c oxidase in Alzheimer’s disease // Neurology . 1995; 45 (7): 1423 .</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">.McRae T., Orazem J. A large-scale, open-label trial of donepezil in the treatment of Alzheimer’s Disease: side-effects and concomitant medication use . Internal Journal of Neiropharmacology 1999; 2 (Suppl 1): 176</mixed-citation><mixed-citation xml:lang="en">.McRae T., Orazem J. A large-scale, open-label trial of donepezil in the treatment of Alzheimer’s Disease: side-effects and concomitant medication use . Internal Journal of Neiropharmacology 1999; 2 (Suppl 1): 176</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">.Mesulam M., Guillozet A., Shaw P., Quinn B. Widely spread butyrylcholinesterase can hydrolyze acetylcholine in the normal and Alzheimer brain . Neurobiology of Disease .2002; 9:88 –93</mixed-citation><mixed-citation xml:lang="en">.Mesulam M., Guillozet A., Shaw P., Quinn B. Widely spread butyrylcholinesterase can hydrolyze acetylcholine in the normal and Alzheimer brain . Neurobiology of Disease .2002; 9:88 –93</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">.Nordberg A, Svensson AL. Cholinesterase inhibitors in the treatment of Alzheimer’s disease: a comparison of tolerability and pharmacology . Drug Safety . 1998; 19 (6): 465-480 . Review . Erratum in: Drug Safety 1999; 20 (2): 146</mixed-citation><mixed-citation xml:lang="en">.Nordberg A, Svensson AL. Cholinesterase inhibitors in the treatment of Alzheimer’s disease: a comparison of tolerability and pharmacology . Drug Safety . 1998; 19 (6): 465-480 . Review . Erratum in: Drug Safety 1999; 20 (2): 146</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">.Nordberg A., Darreh-Shori T., Svensson A., Guan Z. Acetylcholinesterase and butyrylcholinesterase activities in CSF of mild AD patients following 12 months of rivastigmine treatment . Journal of neurological sciences 2001; 187 (suppl 1): P0144</mixed-citation><mixed-citation xml:lang="en">.Nordberg A., Darreh-Shori T., Svensson A., Guan Z. Acetylcholinesterase and butyrylcholinesterase activities in CSF of mild AD patients following 12 months of rivastigmine treatment . Journal of neurological sciences 2001; 187 (suppl 1): P0144</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">.Nordberg A., Stefanova E., Almkvist O., et al. Improved cortical glucose metabolism in Alzheimer’s Disease patients treated with rivastigmine for 1 year . Journal of Neurology Science 2001; 187 (Suppl 1): P0142</mixed-citation><mixed-citation xml:lang="en">.Nordberg A., Stefanova E., Almkvist O., et al. Improved cortical glucose metabolism in Alzheimer’s Disease patients treated with rivastigmine for 1 year . Journal of Neurology Science 2001; 187 (Suppl 1): P0142</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">.Olin J., Schneider L. Galantamine for Alzheimer’s disease . Cochrane Database of Systematic Reviews 2001; (4): CD001747 . Review . Update in: Cochrane Database of Systematic Reviews . 2002; (3):CD001747 .</mixed-citation><mixed-citation xml:lang="en">.Olin J., Schneider L. Galantamine for Alzheimer’s disease . Cochrane Database of Systematic Reviews 2001; (4): CD001747 . Review . Update in: Cochrane Database of Systematic Reviews . 2002; (3):CD001747 .</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">.Perry E.K., Perry R.H., Blessed G., Tomlinson B.E. Changes in brain cholinesterases in senile dementia of Alzheimer type . Neuropathology and Applied Neurobiology . 1978; 4: 273 –277</mixed-citation><mixed-citation xml:lang="en">.Perry E.K., Perry R.H., Blessed G., Tomlinson B.E. Changes in brain cholinesterases in senile dementia of Alzheimer type . Neuropathology and Applied Neurobiology . 1978; 4: 273 –277</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">.Poirier J. Evidence that the clinical effects of cholinesterase inhibitors are related to potency and targeting of action [review] . International Journal of Clinical Practice . 2002; Suppl . 127: 6 –19</mixed-citation><mixed-citation xml:lang="en">.Poirier J. Evidence that the clinical effects of cholinesterase inhibitors are related to potency and targeting of action [review] . International Journal of Clinical Practice . 2002; Suppl . 127: 6 –19</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">.Potkin S.G., Messina J., Graham S. Safety of rivastigmine in Alzheimer’s Disease: pooled results from phase III studies . Poster presented at the World Alzheimer Congress, Washington, USA, July 9-13, 2000</mixed-citation><mixed-citation xml:lang="en">.Potkin S.G., Messina J., Graham S. Safety of rivastigmine in Alzheimer’s Disease: pooled results from phase III studies . Poster presented at the World Alzheimer Congress, Washington, USA, July 9-13, 2000</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">.Prasad K.N., Cole W.C., Hovland A.R., Prasad K.C., Nahreini P., et al. Multiple antioxidants in the prevention and treatment of neurodegenerative disease: analysis of biologic rationale . Current Opinion in Neurology . 1999; 12 (6): 761-770 .</mixed-citation><mixed-citation xml:lang="en">.Prasad K.N., Cole W.C., Hovland A.R., Prasad K.C., Nahreini P., et al. Multiple antioxidants in the prevention and treatment of neurodegenerative disease: analysis of biologic rationale . Current Opinion in Neurology . 1999; 12 (6): 761-770 .</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">.Pratt R. results of clinical studies with donepezil in vascular dementia . Presented at the 2nd International Congress on Vascular Dementia, Salzburg, Austria, January 24-27, 2002</mixed-citation><mixed-citation xml:lang="en">.Pratt R. results of clinical studies with donepezil in vascular dementia . Presented at the 2nd International Congress on Vascular Dementia, Salzburg, Austria, January 24-27, 2002</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">.Qizilbash N., Birks J., Lopez-Arrieta J., Lewington S., Szeto S. Tacrine for Alzheimer’s disease . Cochrane Database Systematic Review . 2000; (2): CD000202 . Update in: Cochrane Database Systematic Review . 2000; (3): CD000202 .</mixed-citation><mixed-citation xml:lang="en">.Qizilbash N., Birks J., Lopez-Arrieta J., Lewington S., Szeto S. Tacrine for Alzheimer’s disease . Cochrane Database Systematic Review . 2000; (2): CD000202 . Update in: Cochrane Database Systematic Review . 2000; (3): CD000202 .</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">.Raskind M., Truyn L. Galantamine has longterm cognitive benefits in Alzheimer’s Disease — an analysis of responder rates at 36 months . Poster presented at the 7th International symposium on Advances in Alzheimer Therapy, Geneva, Switzerland, 3-6 April 2002</mixed-citation><mixed-citation xml:lang="en">.Raskind M., Truyn L. Galantamine has longterm cognitive benefits in Alzheimer’s Disease — an analysis of responder rates at 36 months . Poster presented at the 7th International symposium on Advances in Alzheimer Therapy, Geneva, Switzerland, 3-6 April 2002</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">.Raskind M.A., Peskind E.R., Wessel T., Yuan W. Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension . The Galantamine USA-1 Study Group . Neurology . 2000; 54 (12): 2261-2268 .</mixed-citation><mixed-citation xml:lang="en">.Raskind M.A., Peskind E.R., Wessel T., Yuan W. Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension . The Galantamine USA-1 Study Group . Neurology . 2000; 54 (12): 2261-2268 .</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">.Reading P.J., Luce A.K., McKeith I.G. Rivastigmine in the treatment of parkinsonian psychosis and cognitive impairment: preliminary findings from an open trial . Movement Disorders . 2001; 16 (6): 1171-1174</mixed-citation><mixed-citation xml:lang="en">.Reading P.J., Luce A.K., McKeith I.G. Rivastigmine in the treatment of parkinsonian psychosis and cognitive impairment: preliminary findings from an open trial . Movement Disorders . 2001; 16 (6): 1171-1174</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">.Rockwood K., Kershaw P, on behalf of the Galanthamine International-2 Study Group . Galanthamine’s clinical benefits are not offset by sleep disturbance: a 3-month placebo-controlled study in patients with Alzheimer’s Disease . Poster presented at the World Alzheimer Congress, Washington, USA, July 9-13, 2000</mixed-citation><mixed-citation xml:lang="en">.Rockwood K., Kershaw P, on behalf of the Galanthamine International-2 Study Group . Galanthamine’s clinical benefits are not offset by sleep disturbance: a 3-month placebo-controlled study in patients with Alzheimer’s Disease . Poster presented at the World Alzheimer Congress, Washington, USA, July 9-13, 2000</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">.Rogers S.L., Cooper N.M., Sukovaty R., Pederson J.E., Lee J.N., et al. Pharmacokinetic and pharmacodynamic profile of donepezil HCl following multiple oral doses . British Journal of Clinical Pharmacology . 1998; 46 Suppl 1: 7-12</mixed-citation><mixed-citation xml:lang="en">.Rogers S.L., Cooper N.M., Sukovaty R., Pederson J.E., Lee J.N., et al. Pharmacokinetic and pharmacodynamic profile of donepezil HCl following multiple oral doses . British Journal of Clinical Pharmacology . 1998; 46 Suppl 1: 7-12</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">.Rogers S.L., Doody R.S., Mohs R.C., Friedhoff L.T. Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study . Donepezil Study Group . Archives of Internal Medicine . 1998; 158 (9): 1021-1031</mixed-citation><mixed-citation xml:lang="en">.Rogers S.L., Doody R.S., Mohs R.C., Friedhoff L.T. Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study . Donepezil Study Group . Archives of Internal Medicine . 1998; 158 (9): 1021-1031</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">.Rogers S.L., Farlow M.R., Doody R.S., Mohs R., Friedhoff L.T. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer’s disease . Donepezil Study Group . Neurology . 1998; 50 (1): 136-145</mixed-citation><mixed-citation xml:lang="en">.Rogers S.L., Farlow M.R., Doody R.S., Mohs R., Friedhoff L.T. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer’s disease . Donepezil Study Group . Neurology . 1998; 50 (1): 136-145</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">.Rosler M. The efficacy of cholinesterase inhibitors in treating the behavioural symptoms of dementia . International Journal of Clinical Practice . 2002; Suppl (127): 20-36</mixed-citation><mixed-citation xml:lang="en">.Rosler M. The efficacy of cholinesterase inhibitors in treating the behavioural symptoms of dementia . International Journal of Clinical Practice . 2002; Suppl (127): 20-36</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">.Rosler M., Anand R., Cicin-Sain A., et al. Safety and efficacy of rivastigmine in patients with Alzheimer’s Disease: results of an international, 26-weeks, multicenter, randomised, placebo-controlled trial // BMJ 1999; 318: 633-638</mixed-citation><mixed-citation xml:lang="en">.Rosler M., Anand R., Cicin-Sain A., et al. Safety and efficacy of rivastigmine in patients with Alzheimer’s Disease: results of an international, 26-weeks, multicenter, randomised, placebo-controlled trial // BMJ 1999; 318: 633-638</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">.Rosler M., Retz W., Retz-Junginger P., Dennler H.J. Effects of two-year treatment with the cholinesterase inhibitor rivastigmine on behavioural symptoms in Alzheimer’s disease . Behavioural Neurology . 1998; 11 (4): 211-216</mixed-citation><mixed-citation xml:lang="en">.Rosler M., Retz W., Retz-Junginger P., Dennler H.J. Effects of two-year treatment with the cholinesterase inhibitor rivastigmine on behavioural symptoms in Alzheimer’s disease . Behavioural Neurology . 1998; 11 (4): 211-216</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">.Schmitt B., Bernhardt T., Moeller H.-J., Heuser I., Frolich. L. Combination therapy in Alzheimer’s Disease . CNS Drugs 2004; 18 (13): 827-844</mixed-citation><mixed-citation xml:lang="en">.Schmitt B., Bernhardt T., Moeller H.-J., Heuser I., Frolich. L. Combination therapy in Alzheimer’s Disease . CNS Drugs 2004; 18 (13): 827-844</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">.Schneider L.S., Dagerman K.S., Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials // JAMA . 2005; 294 (15): 1934-1943</mixed-citation><mixed-citation xml:lang="en">.Schneider L.S., Dagerman K.S., Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials // JAMA . 2005; 294 (15): 1934-1943</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">.Shepherd G., Klein-Schwartz W., Edwards R. Donepezil overdose: a tenfold dosing error . Annals of Pharmacotherapy . 1999; 33 (7-8): 812-815</mixed-citation><mixed-citation xml:lang="en">.Shepherd G., Klein-Schwartz W., Edwards R. Donepezil overdose: a tenfold dosing error . Annals of Pharmacotherapy . 1999; 33 (7-8): 812-815</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">.Shua-Haim J.R., Smith J.M., Amin S. Safety and tolerability of slow titration o rivastigmine in the treatment of patients with Alzheimer’s Disease: an overall analysis of two prospective studies . Poster presented at the American Geriatrics Society Annual Scientific Meeting: Chicago, Ilinois, 9-13 May 2001; Abstract P202</mixed-citation><mixed-citation xml:lang="en">.Shua-Haim J.R., Smith J.M., Amin S. Safety and tolerability of slow titration o rivastigmine in the treatment of patients with Alzheimer’s Disease: an overall analysis of two prospective studies . Poster presented at the American Geriatrics Society Annual Scientific Meeting: Chicago, Ilinois, 9-13 May 2001; Abstract P202</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">.Siek G.C., Katz L.S., Fishman E.B., Korosi T.S., Marquis J.K. Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain . Biological Psychiatry . 1990; 27 (6): 573-580</mixed-citation><mixed-citation xml:lang="en">.Siek G.C., Katz L.S., Fishman E.B., Korosi T.S., Marquis J.K. Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain . Biological Psychiatry . 1990; 27 (6): 573-580</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">.Staff R.T., Gemmell H.G., Shanks M.F., Murray A.D., Venneri A. Changes in the rCBF images of patients with Alzheimer’s disease receiving Donepezil therapy . Nuclear Medicine Communications . 2000; 21 (1): 37-41</mixed-citation><mixed-citation xml:lang="en">.Staff R.T., Gemmell H.G., Shanks M.F., Murray A.D., Venneri A. Changes in the rCBF images of patients with Alzheimer’s disease receiving Donepezil therapy . Nuclear Medicine Communications . 2000; 21 (1): 37-41</mixed-citation></citation-alternatives></ref><ref id="cit104"><label>104</label><citation-alternatives><mixed-citation xml:lang="ru">.Stahl S., Markowitz J., Gutterman E. Aricept (donepezil) is associated with incresed hypnotis use among Alzheimer’s Disease patients living in the community . Poster presented in the International Psychogeriatric Association Meeting, Nice, France, 9-14 September, 2001</mixed-citation><mixed-citation xml:lang="en">.Stahl S., Markowitz J., Gutterman E. Aricept (donepezil) is associated with incresed hypnotis use among Alzheimer’s Disease patients living in the community . Poster presented in the International Psychogeriatric Association Meeting, Nice, France, 9-14 September, 2001</mixed-citation></citation-alternatives></ref><ref id="cit105"><label>105</label><citation-alternatives><mixed-citation xml:lang="ru">.Tariot P.N., Solomon P.R., Morris J.C., Kershaw P., Lilienfeld S., Ding C. A 5-month, randomized, placebo-controlled trial of galantamine in AD . The Galantamine USA-10 Study Group . Neurology . 2000 Jun 27;54(12):2269-76</mixed-citation><mixed-citation xml:lang="en">.Tariot P.N., Solomon P.R., Morris J.C., Kershaw P., Lilienfeld S., Ding C. A 5-month, randomized, placebo-controlled trial of galantamine in AD . The Galantamine USA-10 Study Group . Neurology . 2000 Jun 27;54(12):2269-76</mixed-citation></citation-alternatives></ref><ref id="cit106"><label>106</label><citation-alternatives><mixed-citation xml:lang="ru">.Thomsen T., Kaden B., Fischer J.P., Bickel U., Barz H., et al. Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine . European Journal of Clinical Chemistry and Clinical Biochemistry . 1991; 29 (8): 487-492</mixed-citation><mixed-citation xml:lang="en">.Thomsen T., Kaden B., Fischer J.P., Bickel U., Barz H., et al. Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine . European Journal of Clinical Chemistry and Clinical Biochemistry . 1991; 29 (8): 487-492</mixed-citation></citation-alternatives></ref><ref id="cit107"><label>107</label><citation-alternatives><mixed-citation xml:lang="ru">.Thomsen T., Kewitz H. Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo . Life Science . 1990; 46 (21): 1553-1558</mixed-citation><mixed-citation xml:lang="en">.Thomsen T., Kewitz H. Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo . Life Science . 1990; 46 (21): 1553-1558</mixed-citation></citation-alternatives></ref><ref id="cit108"><label>108</label><citation-alternatives><mixed-citation xml:lang="ru">.van Dongen M.C., van Rossum E., Kessels A.G., et al. The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: new results of a randomized clinical trial . Journal of American Geriatric Society 2000; 48: 1183-1194</mixed-citation><mixed-citation xml:lang="en">.van Dongen M.C., van Rossum E., Kessels A.G., et al. The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: new results of a randomized clinical trial . Journal of American Geriatric Society 2000; 48: 1183-1194</mixed-citation></citation-alternatives></ref><ref id="cit109"><label>109</label><citation-alternatives><mixed-citation xml:lang="ru">.Vellas B., Inglis F., Potkin S., et al. Interim results from an international clinical trials with rivastigmine evaluating a 2-week titration rate in mild to severe Alzheimer’s Disease patients . International Journal of Geriatric Psychopharmacology 1998; 1: 140-144</mixed-citation><mixed-citation xml:lang="en">.Vellas B., Inglis F., Potkin S., et al. Interim results from an international clinical trials with rivastigmine evaluating a 2-week titration rate in mild to severe Alzheimer’s Disease patients . International Journal of Geriatric Psychopharmacology 1998; 1: 140-144</mixed-citation></citation-alternatives></ref><ref id="cit110"><label>110</label><citation-alternatives><mixed-citation xml:lang="ru">.Venneri A., Shanks M.F., Staj R.T., et al. Cerebral blood flow and cognitive responses to rivastigmine treatment in Alzheimer’s Disease . Neiroreport 2—2; 13: 83-96</mixed-citation><mixed-citation xml:lang="en">.Venneri A., Shanks M.F., Staj R.T., et al. Cerebral blood flow and cognitive responses to rivastigmine treatment in Alzheimer’s Disease . Neiroreport 2—2; 13: 83-96</mixed-citation></citation-alternatives></ref><ref id="cit111"><label>111</label><citation-alternatives><mixed-citation xml:lang="ru">.Voisin T., Reynish E., Portet F., Feldman H., Vellas B. What are the treatment options for patient with severe Alzheimer’s Disease? CNS Drugs 2004; 18 (9): 575-583</mixed-citation><mixed-citation xml:lang="en">.Voisin T., Reynish E., Portet F., Feldman H., Vellas B. What are the treatment options for patient with severe Alzheimer’s Disease? CNS Drugs 2004; 18 (9): 575-583</mixed-citation></citation-alternatives></ref><ref id="cit112"><label>112</label><citation-alternatives><mixed-citation xml:lang="ru">.Wallin A., Gottfries C.G., Karlsson I., Svennerholm L. Decreased myelin lipids in Alzheimer’s disease and vascular dementia . Acta Neurologica Scandinavica . 1989; 80 (4): 319-323 .</mixed-citation><mixed-citation xml:lang="en">.Wallin A., Gottfries C.G., Karlsson I., Svennerholm L. Decreased myelin lipids in Alzheimer’s disease and vascular dementia . Acta Neurologica Scandinavica . 1989; 80 (4): 319-323 .</mixed-citation></citation-alternatives></ref><ref id="cit113"><label>113</label><citation-alternatives><mixed-citation xml:lang="ru">.Weinstock M. Selectivity of cholinesterase inhibition: clinical implications for the treatment of Alzheimer’s disease . CNS Drugs . 1999; 12 (4): 307 –323</mixed-citation><mixed-citation xml:lang="en">.Weinstock M. Selectivity of cholinesterase inhibition: clinical implications for the treatment of Alzheimer’s disease . CNS Drugs . 1999; 12 (4): 307 –323</mixed-citation></citation-alternatives></ref><ref id="cit114"><label>114</label><citation-alternatives><mixed-citation xml:lang="ru">.Wengel S.P., Roccaforte W.H., Burke W.J., Bayer B.L., McNeilly D.P., et al. Behavioral complications associated with donepezil . American Journal of Psychiatry . 1998; 155 (11): 1632-1623 .</mixed-citation><mixed-citation xml:lang="en">.Wengel S.P., Roccaforte W.H., Burke W.J., Bayer B.L., McNeilly D.P., et al. Behavioral complications associated with donepezil . American Journal of Psychiatry . 1998; 155 (11): 1632-1623 .</mixed-citation></citation-alternatives></ref><ref id="cit115"><label>115</label><citation-alternatives><mixed-citation xml:lang="ru">.Wiebusch H, Poirier J, Sevigny P, Schappert K. Further evidence for a synergistic association between APOE epsilon4 and BCHE-K in confirmed Alzheimer’s disease // Hum Genet 1999; 104: 158-163</mixed-citation><mixed-citation xml:lang="en">.Wiebusch H, Poirier J, Sevigny P, Schappert K. Further evidence for a synergistic association between APOE epsilon4 and BCHE-K in confirmed Alzheimer’s disease // Hum Genet 1999; 104: 158-163</mixed-citation></citation-alternatives></ref><ref id="cit116"><label>116</label><citation-alternatives><mixed-citation xml:lang="ru">.Wilcock G.K., Lilienfeld S., Gaens E. Efficacy and safety of galantamine in patients with mild to moderate Alzheimer’s disease: multicentre randomised controlled trial . Galantamine International-1 Study Group . BMJ . 2000; 321 (7274): 1445-1449 . Erratum in: BMJ 2001; 322 (7283): 405 .</mixed-citation><mixed-citation xml:lang="en">.Wilcock G.K., Lilienfeld S., Gaens E. Efficacy and safety of galantamine in patients with mild to moderate Alzheimer’s disease: multicentre randomised controlled trial . Galantamine International-1 Study Group . BMJ . 2000; 321 (7274): 1445-1449 . Erratum in: BMJ 2001; 322 (7283): 405 .</mixed-citation></citation-alternatives></ref><ref id="cit117"><label>117</label><citation-alternatives><mixed-citation xml:lang="ru">.Wilkinson D.G., Passmore P., Smith R. et al. Comparison of the tolerability, ease of use and efficacy of donepezil and Exelon in Alzheimer’s Disease patients: a 12-weeks multonational study . Presented at the 53rd Annual Meeting of the ФФТб Philadelphia, 5-12 May 2001</mixed-citation><mixed-citation xml:lang="en">.Wilkinson D.G., Passmore P., Smith R. et al. Comparison of the tolerability, ease of use and efficacy of donepezil and Exelon in Alzheimer’s Disease patients: a 12-weeks multonational study . Presented at the 53rd Annual Meeting of the ФФТб Philadelphia, 5-12 May 2001</mixed-citation></citation-alternatives></ref><ref id="cit118"><label>118</label><citation-alternatives><mixed-citation xml:lang="ru">.Winblad B., Poritis N. Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine) . International Journal of Geriatric Psychiatry . 1999; 14 (2): 135-146</mixed-citation><mixed-citation xml:lang="en">.Winblad B., Poritis N. Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine) . International Journal of Geriatric Psychiatry . 1999; 14 (2): 135-146</mixed-citation></citation-alternatives></ref><ref id="cit119"><label>119</label><citation-alternatives><mixed-citation xml:lang="ru">.www .medlux .ru, апрель 2009 г .</mixed-citation><mixed-citation xml:lang="en">.www .medlux .ru, апрель 2009 г .</mixed-citation></citation-alternatives></ref><ref id="cit120"><label>120</label><citation-alternatives><mixed-citation xml:lang="ru">.www .merz .ru/acatinol .php</mixed-citation><mixed-citation xml:lang="en">.www .merz .ru/acatinol .php</mixed-citation></citation-alternatives></ref><ref id="cit121"><label>121</label><citation-alternatives><mixed-citation xml:lang="ru">.www .rmbc .ru, 2009 г .</mixed-citation><mixed-citation xml:lang="en">.www .rmbc .ru, 2009 г .</mixed-citation></citation-alternatives></ref><ref id="cit122"><label>122</label><citation-alternatives><mixed-citation xml:lang="ru">.Xie W., Stribley J.A., Chatonnet A., Wilder P.J., Rizzino A., et al. Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase . Journal of Pharmacology and Experimantal Therapeutics . 2000; 293 (3): 896-902</mixed-citation><mixed-citation xml:lang="en">.Xie W., Stribley J.A., Chatonnet A., Wilder P.J., Rizzino A., et al. Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase . Journal of Pharmacology and Experimantal Therapeutics . 2000; 293 (3): 896-902</mixed-citation></citation-alternatives></ref><ref id="cit123"><label>123</label><citation-alternatives><mixed-citation xml:lang="ru">.Olin J., Schneider L. Galantamine for Alzheimer’s disease . Cochrane Database of Systematic Reviews 2001; (4): CD001747 . Review . Update in: Cochrane Database of Systematic Reviews . 2002; (3):CD001747 .</mixed-citation><mixed-citation xml:lang="en">.Olin J., Schneider L. Galantamine for Alzheimer’s disease . Cochrane Database of Systematic Reviews 2001; (4): CD001747 . Review . Update in: Cochrane Database of Systematic Reviews . 2002; (3):CD001747 .</mixed-citation></citation-alternatives></ref><ref id="cit124"><label>124</label><citation-alternatives><mixed-citation xml:lang="ru">.Wimo A., Winblad B., Aguero-Torres H., Von Strauss E. The magnitude of dementia occurence in the world . Alzheimer Dis . Assoc . Disord . 2003;17 (2): 63-67</mixed-citation><mixed-citation xml:lang="en">.Wimo A., Winblad B., Aguero-Torres H., Von Strauss E. The magnitude of dementia occurence in the world . Alzheimer Dis . Assoc . Disord . 2003;17 (2): 63-67</mixed-citation></citation-alternatives></ref><ref id="cit125"><label>125</label><citation-alternatives><mixed-citation xml:lang="ru">.Fratiglioni L., Launer L.J., Andersen K. et al. Incidence of dementia and major subtypes in Europe: A collaborative study of population based cohort . Neurologic Diseases in the Elderly Research Group . Neurology 2000; 54 (11 suppl 5): 10-15</mixed-citation><mixed-citation xml:lang="en">.Fratiglioni L., Launer L.J., Andersen K. et al. Incidence of dementia and major subtypes in Europe: A collaborative study of population based cohort . Neurologic Diseases in the Elderly Research Group . Neurology 2000; 54 (11 suppl 5): 10-15</mixed-citation></citation-alternatives></ref><ref id="cit126"><label>126</label><citation-alternatives><mixed-citation xml:lang="ru">.Wimo A., Winblad B., Jonsson L. An estimate of the total worldwide societal costs of dementia in 2005 . Alheimers Dement . 2007; 3: 81-91</mixed-citation><mixed-citation xml:lang="en">.Wimo A., Winblad B., Jonsson L. An estimate of the total worldwide societal costs of dementia in 2005 . Alheimers Dement . 2007; 3: 81-91</mixed-citation></citation-alternatives></ref><ref id="cit127"><label>127</label><citation-alternatives><mixed-citation xml:lang="ru">.Machado J.C., Caramelli P. Treatment of dementia: anything new? Curr . Opin . Psychiatry 2006; 19 (6): 575-580</mixed-citation><mixed-citation xml:lang="en">.Machado J.C., Caramelli P. Treatment of dementia: anything new? Curr . Opin . Psychiatry 2006; 19 (6): 575-580</mixed-citation></citation-alternatives></ref><ref id="cit128"><label>128</label><citation-alternatives><mixed-citation xml:lang="ru">.Imbimbo B.P. Pharmacodinamic-tolerability relationships of cholinesterase inhibitors for Alzheimer’s disease . CNS Drugs 2001; 15 (5): 375-390</mixed-citation><mixed-citation xml:lang="en">.Imbimbo B.P. Pharmacodinamic-tolerability relationships of cholinesterase inhibitors for Alzheimer’s disease . CNS Drugs 2001; 15 (5): 375-390</mixed-citation></citation-alternatives></ref><ref id="cit129"><label>129</label><citation-alternatives><mixed-citation xml:lang="ru">.Schneider L.S., Anand R., Farlow M.R. Systematic review of the efficacy of rivastigmine for patients with Alzheimer’s disease . Int . J . Geriatr . Psychopharmacol . 1998; 1 (suppl . 1): 26-34</mixed-citation><mixed-citation xml:lang="en">.Schneider L.S., Anand R., Farlow M.R. Systematic review of the efficacy of rivastigmine for patients with Alzheimer’s disease . Int . J . Geriatr . Psychopharmacol . 1998; 1 (suppl . 1): 26-34</mixed-citation></citation-alternatives></ref><ref id="cit130"><label>130</label><citation-alternatives><mixed-citation xml:lang="ru">.Petersen T.A. Transdermal drug formulations and process development . Pharm . Technol . 2003; (Suppl): 18-21</mixed-citation><mixed-citation xml:lang="en">.Petersen T.A. Transdermal drug formulations and process development . Pharm . Technol . 2003; (Suppl): 18-21</mixed-citation></citation-alternatives></ref><ref id="cit131"><label>131</label><citation-alternatives><mixed-citation xml:lang="ru">.Winblad B., Machado J.C. Use of rivastigmine transdermal patch in the treatment of Alzheimer’s disease . Expert Opin . drug Deliv . 2008; 5 (12): 1-10</mixed-citation><mixed-citation xml:lang="en">.Winblad B., Machado J.C. Use of rivastigmine transdermal patch in the treatment of Alzheimer’s disease . Expert Opin . drug Deliv . 2008; 5 (12): 1-10</mixed-citation></citation-alternatives></ref><ref id="cit132"><label>132</label><citation-alternatives><mixed-citation xml:lang="ru">.Lefevre G., Sedek G., Jhee S. et al. Pharmacokinetics and pharmacodynamics of the novel daily rivastigmine transdermal patch compare with twice-daily capsules in Alzheimer’s disease patients . Clin . Pharm . Ther . 2008; 83 (1): 106-114</mixed-citation><mixed-citation xml:lang="en">.Lefevre G., Sedek G., Jhee S. et al. Pharmacokinetics and pharmacodynamics of the novel daily rivastigmine transdermal patch compare with twice-daily capsules in Alzheimer’s disease patients . Clin . Pharm . Ther . 2008; 83 (1): 106-114</mixed-citation></citation-alternatives></ref><ref id="cit133"><label>133</label><citation-alternatives><mixed-citation xml:lang="ru">.Mercier F., Lefevre G., Huang H.L. et al. Rivastigmine exposure provided by a transdermal patch versus capsules . Curr . Med . Res . Opin . 2007; 23:3199-3204</mixed-citation><mixed-citation xml:lang="en">.Mercier F., Lefevre G., Huang H.L. et al. Rivastigmine exposure provided by a transdermal patch versus capsules . Curr . Med . Res . Opin . 2007; 23:3199-3204</mixed-citation></citation-alternatives></ref><ref id="cit134"><label>134</label><citation-alternatives><mixed-citation xml:lang="ru">.Lefevre G., Sedek G., Huang H.L. et al. Pharmacokinetics of a rivastigmine transdermal patch formulation in healthy volunteers: relative effects of body site application . J . Clin . Pharmacol . 2007 ; 47 (4): 471-478</mixed-citation><mixed-citation xml:lang="en">.Lefevre G., Sedek G., Huang H.L. et al. Pharmacokinetics of a rivastigmine transdermal patch formulation in healthy volunteers: relative effects of body site application . J . Clin . Pharmacol . 2007 ; 47 (4): 471-478</mixed-citation></citation-alternatives></ref><ref id="cit135"><label>135</label><citation-alternatives><mixed-citation xml:lang="ru">.Winblad B., Cummings J., Andreasen N. et al. A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer’s disease — rivastigmine patch versus capsule . Int . J . Geriatr . Psychiatry 2007; 22(5): 456-467</mixed-citation><mixed-citation xml:lang="en">.Winblad B., Cummings J., Andreasen N. et al. A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer’s disease — rivastigmine patch versus capsule . Int . J . Geriatr . Psychiatry 2007; 22(5): 456-467</mixed-citation></citation-alternatives></ref><ref id="cit136"><label>136</label><citation-alternatives><mixed-citation xml:lang="ru">.Singh G, et al J Am Geriatr Soc 2005;53:1269–70</mixed-citation><mixed-citation xml:lang="en">.Singh G, et al J Am Geriatr Soc 2005;53:1269–70</mixed-citation></citation-alternatives></ref><ref id="cit137"><label>137</label><citation-alternatives><mixed-citation xml:lang="ru">.Harada ASM, Vanderplas AM . ISPOR annual meeting, May 20–24, 2006, USA</mixed-citation><mixed-citation xml:lang="en">.Harada ASM, Vanderplas AM . ISPOR annual meeting, May 20–24, 2006, USA</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
